Posted by Caleb462 on May 8, 2003, at 14:35:33
In reply to 5-HT2c Receptor » Caleb462, posted by jack smith on May 8, 2003, at 12:48:57
> > When you take an SSRI, the 5-HT2c receptors become activated to a much greater degree due to all the excess serotonin, which means a larger inhibition of dopamine.
>
> Interesting. But how does serzone avoid hitting this receptor, is it even more selective? Does remeron hit this receptor? Are there any other seratonergic drugs that do not hit this receptor? Perhaps this explains why Celexa pooped out on me?? What do you think?
>
> JACK
>
>Serzone avoids this effect by also being a 5-HT2 antagonist. Meaning it blocks this receptor and prevents the widespread dopamine ihhibition that would otherwise occur if all the serotonin was allowed to bind to it. Remeron is also a 5-HT2 antagonist.
As for why Celexa pooped out... who knows? But I do believe that SSRIs can induce a depressive state, that may or may not be different from the previous depressive state, by inhibiting dopamine release.
poster:Caleb462
thread:225001
URL: http://www.dr-bob.org/babble/20030505/msgs/225159.html