Posted by MB on May 11, 2003, at 2:40:34
In reply to Re: 5-HT2c Receptor » Caleb462, posted by MB on May 11, 2003, at 2:22:54
Another interesting thing about 5HT-2c receptors is that they are initially acivated by the rise in extracellular serotonin levels following initiation of SSRI treatment. Anxiety, appetite loss, and weight loss are usually early side efects of SSRI treatment (and are also effects of 5HT-2c receptor agonism). However, after some time on SSRIs, 5HT-2c receptors become desensitized to serotonin, and it is around this time that the tardive (late onset) weight gain is seen in patients "doing" long-term SSRI therapy. This being the case, adding Serzone or another drug effecting 5HT-2c agonism might be an answer to tardive SSRI weight gain.
Just conjecture,
MB
poster:MB
thread:225001
URL: http://www.dr-bob.org/babble/20030505/msgs/225750.html