Posted by JohnX on October 22, 2001, at 23:25:53
In reply to Nierenberg - Clonidine for bipolar depression?, posted by SLS on October 19, 2001, at 16:44:56
Scott,
One thing is curious.
Bupropion is thought to inhibit firing of neurons
in the primary area affected by the alpha-2 receptors.
Remeron's alpha-2 antagonism increases firing.-john
> Hi Doctor.
>
> I suffer from TRD chronic bipolar depression. Several medications make me feel significantly worse, including mirtazepine and idazoxan. I recently attempted to add mirtazepine to an ongoing trial of venlafaxine. Within 12 hours of my first 7.5mg dose, my condition began to deteriorate in a manner similar to those previous. Might this suggest trying a drug that exerts an opposite effect at NE alpha-2 receptors (e.g. clonidine) ?
>
> I’m upset because the two drug combinations using venlafaxine that my doctor thought would have the best chances of working for me involve using drugs to which I have previously experienced negative reactions – bupropion and mirtazepine.
>
> Thanks.
>
>
> - Scott
poster:JohnX
thread:81697
URL: http://www.dr-bob.org/babble/20011015/msgs/82027.html