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Nierenberg - Clonidine for bipolar depression?

Posted by SLS on October 19, 2001, at 16:44:56

Hi Doctor.

I suffer from TRD chronic bipolar depression. Several medications make me feel significantly worse, including mirtazepine and idazoxan. I recently attempted to add mirtazepine to an ongoing trial of venlafaxine. Within 12 hours of my first 7.5mg dose, my condition began to deteriorate in a manner similar to those previous. Might this suggest trying a drug that exerts an opposite effect at NE alpha-2 receptors (e.g. clonidine) ?

I’m upset because the two drug combinations using venlafaxine that my doctor thought would have the best chances of working for me involve using drugs to which I have previously experienced negative reactions – bupropion and mirtazepine.

Thanks.


- Scott

 

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