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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 11 of 11. This is the beginning of the thread.
Posted by Amigan on July 23, 2008, at 11:13:00
One of the S in NaSSa stands for Serotonergic. Why Mirtazapine is considered Serotonergic?
It's not a Serotonin releaser
It's not a Serotonin reuptake inhibitor
It's not a Serotonin autoreceptor agonist
It doesn't enhance Serotonergic transmission.It's a selective, post-synaptic Serotonin antagonist. Calling this Serotonergic, is like calling Haloperidol Dopaminergic.
Is there an error in my reasoning?
Posted by Amigan on July 23, 2008, at 11:16:43
In reply to Is Mirtazapine really a NaSSa?, posted by Amigan on July 23, 2008, at 11:13:00
> It's not a Serotonin autoreceptor agonist
I meant antagonist. Blocker.
Posted by dbc on July 26, 2008, at 11:57:32
In reply to Re: Is Mirtazapine really a NaSSA?, posted by Amigan on July 23, 2008, at 11:16:43
Its been found to have some serotongenic promoting properties but they have no idea why or how. I assume enough rats died with higher levels of serotonin and they decided it promoted serotonin.
Posted by Crotale on July 27, 2008, at 14:25:58
In reply to Re: Is Mirtazapine really a NaSSA?, posted by dbc on July 26, 2008, at 11:57:32
Anyone actually know exactly what "NaSSA" is supposed to stand for?
-Crotale
Posted by Amigan on July 27, 2008, at 14:29:57
In reply to Re: Is Mirtazapine really a NaSSA?, posted by Crotale on July 27, 2008, at 14:25:58
> Anyone actually know exactly what "NaSSA" is supposed to stand for?
>
Posted by Crotale on July 27, 2008, at 21:50:06
In reply to Re: Is Mirtazapine really a NaSSA?, posted by Amigan on July 27, 2008, at 14:29:57
> > Anyone actually know exactly what "NaSSA" is supposed to stand for?
> >
>
> http://www.shetland-sheep.org
>Very cute.
(Baaaahhhh)
Posted by Racer on July 30, 2008, at 22:27:07
In reply to Re: Is Mirtazapine really a NaSSA?, posted by Amigan on July 27, 2008, at 14:29:57
> > Anyone actually know exactly what "NaSSA" is supposed to stand for?
> >
>
> http://www.shetland-sheep.org
>LOL! As a spinner, I appreciate that site. I even have some shetland wool waiting to be spun up...
Crotale, another meaning is Noradrenergic and Selective Serotonergic Antidepressant.
Posted by Amigan on July 31, 2008, at 12:45:48
In reply to Re: Is Mirtazapine really a NaSSA? »Crotale » Amigan, posted by Racer on July 30, 2008, at 22:27:07
Posted by Questionmark on August 7, 2008, at 1:11:41
In reply to Re: Is Mirtazapine really a NaSSA?, posted by dbc on July 26, 2008, at 11:57:32
It blocks 5-HT1A, 5-HT2A and 5-HT3 receptors i believe. But antagonism of 5ht1A receptors causes enhanced release of serotonin. Therefore it is claimed to promote serotonin transmission and yet block some of the receptors associated with some of the serotonergic side effects.
As a NE alpha-2 antagonist, it works in a similar way with norepinephrine as well, promoting its release in many areas.
> Its been found to have some serotongenic promoting properties but they have no idea why or how. I assume enough rats died with higher levels of serotonin and they decided it promoted serotonin.
Posted by undopaminergic on August 10, 2008, at 7:39:41
In reply to Re: Is Mirtazapine really a NaSSA? » dbc, posted by Questionmark on August 7, 2008, at 1:11:41
Blockade of presynaptic alpha2-receptors accounts for some of mirtazapine's serotonergic effects, as some alpha2-receptors are located on serotonergic nerve terminals and act to inhibit serotonin release.
However, it blocks postsynaptic alpah2-receptors as well, thus ruining your working memory performance. Having tried mirtazapine and guanfacine (alpha2-agonist), I'm of the definite opinion that stimulating alpha2-receptors is a lot better than blocking them.
Posted by Amigan on August 18, 2008, at 13:07:15
In reply to Re: Is Mirtazapine really a NaSSA?, posted by undopaminergic on August 10, 2008, at 7:39:41
> Blockade of presynaptic alpha2-receptors accounts for some of mirtazapine's serotonergic effects, as some alpha2-receptors are located on serotonergic nerve terminals and act to inhibit serotonin release.
I see now. I think that what you have described here could explain why Clonidine has depressogenic properties and why some pure noradrenergic drugs can be useful for depression?
This is the end of the thread.
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