Posted by undopaminergic on August 10, 2008, at 7:39:41
In reply to Re: Is Mirtazapine really a NaSSA? » dbc, posted by Questionmark on August 7, 2008, at 1:11:41
Blockade of presynaptic alpha2-receptors accounts for some of mirtazapine's serotonergic effects, as some alpha2-receptors are located on serotonergic nerve terminals and act to inhibit serotonin release.
However, it blocks postsynaptic alpah2-receptors as well, thus ruining your working memory performance. Having tried mirtazapine and guanfacine (alpha2-agonist), I'm of the definite opinion that stimulating alpha2-receptors is a lot better than blocking them.
poster:undopaminergic
thread:841595
URL: http://www.dr-bob.org/babble/neuro/20080706/msgs/845277.html