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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by stevezen on March 21, 2007, at 17:29:36
hey there everyone! first post here and was just wondering...
I started taking parnate a little over a week ago. I have been finding that dosing first thing when I wake (10mg) augmenting with another 10mg several hours later, is leaving me utterly fatigued and is actually compounding my depression further still.
it is just the first week though, and I'm determined to give this a good go. would taking my dose in one go (20mgs) at night just before bed be a temporary solution until my body get's used to parnate?
I've read many times that parnate is supposed to be stimulating, but it seems to have the opposite effect on me.
I already tried for several nights in a row taking 10mg's just before bed, and 10mg's just as I wake. this has offset the symtoms somewhat, but I'd like to know if taking 20mgs just before bedtime would basically defeat the purpose of taking parnate in the first place.
anyone any thoughts on this?
many thanks
Posted by willyee on March 21, 2007, at 17:35:41
In reply to Parnate: dosing at night to avoid fatigue, posted by stevezen on March 21, 2007, at 17:29:36
> hey there everyone! first post here and was just wondering...
> I started taking parnate a little over a week ago. I have been finding that dosing first thing when I wake (10mg) augmenting with another 10mg several hours later, is leaving me utterly fatigued and is actually compounding my depression further still.
> it is just the first week though, and I'm determined to give this a good go. would taking my dose in one go (20mgs) at night just before bed be a temporary solution until my body get's used to parnate?
> I've read many times that parnate is supposed to be stimulating, but it seems to have the opposite effect on me.
> I already tried for several nights in a row taking 10mg's just before bed, and 10mg's just as I wake. this has offset the symtoms somewhat, but I'd like to know if taking 20mgs just before bedtime would basically defeat the purpose of taking parnate in the first place.
> anyone any thoughts on this?
> many thanksDont do it,sounds somewhat logical i know,but it just doesent work that way,you take it at night expect to be up.
When my depression was or is at its worst,i get a very sick feeling in my stomach,like my gut sinks in cause im always the last one up,so i take at times parnate at this time,now it keeps me up till at least 3 am or later but when i do it which is seldom i usualy dont care because the trade off of feeling better at night and staying up over laying awake ine bed sick as a dog works for the drug.
But i tried what u speak of too,and like one would think when parnate is activating simply take klonopin would make it a great combo,this isnt always so either,these drugs dont like to follow logic the little b----s lol.
Posted by stevezen on March 21, 2007, at 18:16:40
In reply to Re: Parnate: dosing at night to avoid fatigue, posted by willyee on March 21, 2007, at 17:35:41
thanks for the responce willyee!
I dunno, i'm a bit of an od-bod I guess. I can't honestly report on feeling any of the stimulating qualities parante seems to give most folks, quite the opposite in fact. 20mg's just floors me, to the point I can't even hold my head up :(
usually I work out quite rigorously, but parnate makes me feel weaker somehow. I have to wait around 6-7 hours after my morning 10mg dose to pluck up some strength.
I've been taking 10mg's just before sleep, along with .5mgs klonopin, I won't increase that dose of klonopin just coz i'm affraid of tolerance issues.
I know it's just 10mgs so far at night, but it's not affected how I sleep when perhaps it should have done.
but is dosing at night kinda like defeating the purpose of taking parnate in the first place?
am I just sleeping through the postive benefits?
hopefully this fatigue is just temporary and i'll be able to dose throughout the day like most folks.
many thanks
Posted by tessellated on March 21, 2007, at 19:53:31
In reply to Re: Parnate: dosing at night to avoid fatigue, posted by stevezen on March 21, 2007, at 18:16:40
my theory:
maoi inhibition is a highly individualistic variable protein/enzymatic mechanism.
i never felt the benefits of parnate until 6-8 hours after the intial admin. so if i take at 9am, I would wake up at 5-6pm. then dose again and stay up through the night with a distinct congnitive clarity.
it felt like i could never take the first dose early enough, though i regret that i never did attempt to take at night.
i think the dose/response curve is unpredictable, and that's the problem with it. it's a step up from amphetamines, but is more variable.
i do believe my depression to be related to mao, and the maoi's fit in a way like nothing else, but radically influence so much of my physiology it seems like a game of chance.
Posted by stevezen on March 23, 2007, at 17:08:55
In reply to Re: Parnate: dosing at night to avoid fatigue, posted by tessellated on March 21, 2007, at 19:53:31
> my theory:
>
> maoi inhibition is a highly individualistic variable protein/enzymatic mechanism.
>
> i never felt the benefits of parnate until 6-8 hours after the intial admin. so if i take at 9am, I would wake up at 5-6pm. then dose again and stay up through the night with a distinct congnitive clarity.
>
> it felt like i could never take the first dose early enough, though i regret that i never did attempt to take at night.
>
> i think the dose/response curve is unpredictable, and that's the problem with it. it's a step up from amphetamines, but is more variable.
>
> i do believe my depression to be related to mao, and the maoi's fit in a way like nothing else, but radically influence so much of my physiology it seems like a game of chance.
>
>thanks for your reply tessellated.
I guess from what you say that you eventually decided to stop taking parnate. it certainly isn't exactly a good thing to be half asleep all day, then by 5-6pm take a second dose to be up all night! although at least you report the cognative clarity which is one of the reasons I wanted to take parnate. I feel I've been suffering undiagnosed ADD since early childhood, which basically led to me messing up at school and ultimitely depression to cut a very long story short.
I'm continuing with my 10mg's before sleep, and 10mg's when I wake. although still, after the morning dose I'm pretty much a zombie after a few hours and even find myself sleeping on the floor beside a radiator (parnate can make me very cold and sleepy)
it's been nearly two weeks now, and still can't report any lifting of my depression or stimulating qualities although after the second week I will most likely raise my dose to 30mg's.
interesting that you mention parnate to be a step up from amphetamines. I would've really liked to have given adderall a try, unfortunately, here in the UK it's not available to my knowledge.
anyway, I'll keep going with this I think for at least 6 - 8 weeks, raising my dose if I don't feel any relief after each consecutive week, fingers crossed for some kind of responce somewhere down the track.
best wishes, and many thanks
Posted by tessellated on March 24, 2007, at 14:19:49
In reply to Re: Parnate: dosing at night to avoid fatigue, posted by stevezen on March 23, 2007, at 17:08:55
i have a love/hate relationship with parnate.
it is a potent agent, but really enhanced my creativity, drive, ambition, but then when i got up into the 120mg/24hr area, mania would creep in. suddenly, i had not slept for 3 days, but was reading writing volumes, and then feel submerged in an excess of profundity of emotion, etc...generally, not many people get an obvious result until in the range of 60mg for 2-8 days. but many people here are doubling that. i think everyone would recommend to stay as low as possible to reduce side effects and poop out. so its good to move slow.
i think i've done three trials, and everytime i've tried it's been different. frustrating for me long term, but it can be a "life saver".
cheers,
l8
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