Posted by stevezen on March 23, 2007, at 17:08:55
In reply to Re: Parnate: dosing at night to avoid fatigue, posted by tessellated on March 21, 2007, at 19:53:31
> my theory:
>
> maoi inhibition is a highly individualistic variable protein/enzymatic mechanism.
>
> i never felt the benefits of parnate until 6-8 hours after the intial admin. so if i take at 9am, I would wake up at 5-6pm. then dose again and stay up through the night with a distinct congnitive clarity.
>
> it felt like i could never take the first dose early enough, though i regret that i never did attempt to take at night.
>
> i think the dose/response curve is unpredictable, and that's the problem with it. it's a step up from amphetamines, but is more variable.
>
> i do believe my depression to be related to mao, and the maoi's fit in a way like nothing else, but radically influence so much of my physiology it seems like a game of chance.
>
>thanks for your reply tessellated.
I guess from what you say that you eventually decided to stop taking parnate. it certainly isn't exactly a good thing to be half asleep all day, then by 5-6pm take a second dose to be up all night! although at least you report the cognative clarity which is one of the reasons I wanted to take parnate. I feel I've been suffering undiagnosed ADD since early childhood, which basically led to me messing up at school and ultimitely depression to cut a very long story short.
I'm continuing with my 10mg's before sleep, and 10mg's when I wake. although still, after the morning dose I'm pretty much a zombie after a few hours and even find myself sleeping on the floor beside a radiator (parnate can make me very cold and sleepy)
it's been nearly two weeks now, and still can't report any lifting of my depression or stimulating qualities although after the second week I will most likely raise my dose to 30mg's.
interesting that you mention parnate to be a step up from amphetamines. I would've really liked to have given adderall a try, unfortunately, here in the UK it's not available to my knowledge.
anyway, I'll keep going with this I think for at least 6 - 8 weeks, raising my dose if I don't feel any relief after each consecutive week, fingers crossed for some kind of responce somewhere down the track.
best wishes, and many thanks
poster:stevezen
thread:742947
URL: http://www.dr-bob.org/babble/20070320/msgs/743517.html