Posted by tessellated on March 21, 2007, at 19:53:31
In reply to Re: Parnate: dosing at night to avoid fatigue, posted by stevezen on March 21, 2007, at 18:16:40
my theory:
maoi inhibition is a highly individualistic variable protein/enzymatic mechanism.
i never felt the benefits of parnate until 6-8 hours after the intial admin. so if i take at 9am, I would wake up at 5-6pm. then dose again and stay up through the night with a distinct congnitive clarity.
it felt like i could never take the first dose early enough, though i regret that i never did attempt to take at night.
i think the dose/response curve is unpredictable, and that's the problem with it. it's a step up from amphetamines, but is more variable.
i do believe my depression to be related to mao, and the maoi's fit in a way like nothing else, but radically influence so much of my physiology it seems like a game of chance.
poster:tessellated
thread:742947
URL: http://www.dr-bob.org/babble/20070320/msgs/743006.html