Posted by Aya on August 23, 2007, at 11:52:07
In reply to Re: Cymbalta Withdrawal -- Take ACTION, posted by Aya on August 23, 2007, at 11:46:37
I copied this directly from the Cymbalta website. It was not easy to find (and there's no search engine!) but it was there. I believe the document I got it from was the information sheet they give to the doctors. I have a problem with the wording, as it kind of glosses over the severity of these symptoms, and the fact that that specific info wasn't easy to find on the website. I also have a problem with the doctors who are prescribing these meds and claim there are no withdrawal effects. They have not done their research and should not be prescribing something they know so little about (or they're just lying). For those of you with a doctor like this, go to http://pi.lilly.com/us/cymbalta-pi.pdf, print it out for them, and show them the part about withdrawal.
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Discontinuation of Treatment with Cymbalta — Discontinuation symptoms have been systematically evaluated in patients taking duloxetine. Following abrupt discontinuation in placebo-controlled clinical trials, the following symptoms occurred at a rate greater than or equal to 1% and at a significantly higher rate in duloxetine-treated patients compared to those discontinuing from placebo: dizziness; nausea; headache; paresthesia; vomiting; irritability; nightmares; insomnia; diarrhea; anxiety; hyperhidrosis; and vertigo.
During marketing of other SSRIs and SNRIs (serotonin and norepinephrine reuptake inhibitors), there have been spontaneous reports of adverse events occurring upon discontinuation of these drugs, particularly when abrupt, including the following: dysphoric mood, irritability, agitation, dizziness, sensory disturbances (e.g., paresthesias such as electric shock sensations), anxiety, confusion, headache, lethargy, emotional lability, insomnia, hypomania, tinnitus, and seizures. Although these events are generally self-limiting, some have been reported to be severe.
Patients should be monitored for these symptoms when discontinuing treatment with Cymbalta. A gradual reduction in the dose rather than abrupt cessation is recommended whenever possible. If intolerable symptoms occur following a decrease in the dose or upon discontinuation of treatment, then resuming the previously prescribed dose may be considered. Subsequently, the physician may continue decreasing the dose but at a more gradual rate (see DOSAGE AND ADMINISTRATION).
poster:Aya
thread:466069
URL: http://www.dr-bob.org/babble/wdrawl/20070419/msgs/778042.html