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Re: Kappa opioid receptors and dopamine

Posted by undopaminergic on June 2, 2008, at 20:37:31

In reply to Re: Kappa opioid receptors and dopamine, posted by Crotale on June 2, 2008, at 17:34:52

> > I know of one person who, upon adding 25mg of naltrexone to ongoing SSRI treatment, experienced a remarkable antidepressant effect. You can find his posts using the Dr. Bob Google search function and using the keywords "Wayne" and "naltrexone".
>
> This is true, but OTOH, I've heard reports of dysphoria and worsened depression from kappa opioids like butorphanol and pentazocine.
>
> Crotale

Precisely. Hence, blocking kappa opioids - especially endogenous dynorphin - with naltrexone or buprenorphine may have antidepressive effects.


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URL: http://www.dr-bob.org/babble/neuro/20080418/msgs/832593.html