Posted by Larry Hoover on March 24, 2007, at 14:30:52
In reply to Re: How much b6 is safe?, posted by qqqsimmons on March 22, 2007, at 8:37:01
> fyi, excessive doses of b6 may affect male reproductive system:
>
> check pubmed for:Always appreciate the heads-up.
> Effects of megadoses of pyridoxine on spermatogenesis and male reproductive organs in rats
Woi! Those rats were sure seriously megadosed.....up to 1000 mg/kg body weight. Even the lower of the two doses which showed no adverse effects (i.e. 125 and 250 mg/kg) is nearly 10 times what I've been suggesting.
> Androgen hydroxysteroid dehydrogenases under the influence of pyridoxine derivatives
>This latter paper is more about the regulatory differences between pyridoxine and pyridoxal, which seem to be opposed to one another. That's pretty commonplace, actually, where a precursor (pyridoxine) activates, and a downstream product suppresses some biological function. I don't think it's about megadoses at all.
Thanks again.
Lar
poster:Larry Hoover
thread:742858
URL: http://www.dr-bob.org/babble/alter/20070320/msgs/743727.html