Posted by tealady on November 18, 2003, at 5:28:48
In reply to Tyrosine Triptophane ? , posted by Francesco on November 18, 2003, at 4:17:06
>
> I've also experienced muscle-ache problems with triptophane. It is normal ?
Hmmm I would stop the tryptophan if I had that reaction...
Here's my post before to Mathhh when I was concerned about the comments implying one could safely take unlimited amounts of this stuff ....
http://www.dr-bob.org/babble/alter/20030903/msgs/263032.htmlIf you click on the link there you get "The Eosinophilia-Myalgia Syndrome
The eosinophilia-myalgia syndrome (EMS) afflicted thousands, killed dozens and lingers in hundreds of victims to this day. It resembles a chronic autoimmune disease, with ACHING JOINTS AND MUSCLES, elevated white blood cells (eosinophils), fever, skin rash and fibrosis (hardening), swollen limbs, weakness and such long-term complications as lung disease (including pulmonary hypertension) and cognitive impairment"Note the aching joints and muscles?
Personally I don't know enough to really comment , but I'd be stopping it if It was me.I do have a few other concerns wuth tryptophan that I didn't mention at that time. Perhaps I should put them up for discussion now
This is a comment I saw from a doc a while ago...
(http://forums.about.com/ab-thyroid/messages?msg=6675.139)"Abnormalities in individual metabolism result in highly charged metabolic byproducts....indicans, xantheurenic acid, kyneurenic acid, which interact with cell membranes causing them to "leak.""
Here's some references
http://bmc.ub.uni-potsdam.de/1472-6793-1-7/
"Xanthurenic acid is formed upon tryptophan degradation by indoleamine-2,3 dioxygenase (IDO). The end products of this degradation pathway are, alternatively, nicotinate and xanthurenic acid. IDO activity is stimulated by superoxide radicals, liposaccharides and interferon-γ [1]. Kynurenine aminotransferase (KAT), the enzyme directly responsible for xanthurenic acid formation from 3-hydroxykynurenine, is found in the cytoplasm and mitochondria, and is highly expressed in the retina [2,3]. Xanthurenic acid is present in blood and urine at concentrations of 0.7 and 5-10 μM, respectively [4,5]. A several - fold increase is observed in vitamin B6 deficiency and some diseases such as tuberculosis [6,7]. Xanthurenic acid's presence in the blood is linked to malaria development, and in the lenses to senile cataract formation [8,9,10]. Xanthurenic acid binds covalently to proteins, leads to their unfolding, and to cell death [11]. Here, we report that xanthurenic acid induces cell death associated with caspase-3, -8, and -9 activation, nuclear DNA cleavage, and cytochrome C release"
"The results indicate that xanthurenic acid is an important factor involved in aging and disease development. "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11867954&dopt=Abstract
"Tryptophan metabolism via the kynurenine pathway in experimental chronic renal failure.Pawlak D, Tankiewicz A, Mysliwiec P, Buczko W.
Department of Pharmacodynamics, Medical Academy of Bialystok, Poland. dariuszpawlak@poczta.onet.pl
BACKGROUND: Kidneys are involved in tryptophan (TRP) metabolism in two ways. They eliminate TRP derivatives on the one hand, and they produce several enzymes taking part in TRP metabolism mainly via the kynurenine pathway on the other. The aim of the present study was to examine the time-course of changes in the peripheral kynurenine products degradation during experimental chronic renal failure in rats. METHODS: Tryptophan, kynurenine, 3-hydroxykynurenine, kynurenic acid, xanthurenic acid, anthranilic acid and quinolinic acid were determined in plasma using high-performance liquid chromatography technique with UV, fluorescence and electrochemical detection. RESULTS: A decreased TRP level and significant increase in kynurenine pathway metabolite concentrations in plasma of uremic rats were found. CONCLUSIONS: Substantial disturbances in the peripheral kynurenic pathway were observed in experimental chronic renal failure. They may contribute to several symptoms of uremia. Copyright 2002 S. Karger AG, Basel"
google for lots of info on
Also note kynurenine acid levels and schizophrenia are linked
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11684348&dopt=AbstractThat's why so far, I'm sticking to the foods..even if they ain't working too good so far
Jan
>
poster:tealady
thread:280767
URL: http://www.dr-bob.org/babble/alter/20031104/msgs/280769.html