Posted by SLS on September 10, 2010, at 8:03:54
In reply to Re: Another semi failed trial » SLS, posted by linkadge on September 10, 2010, at 7:52:20
> > What would be the effect of the partial 5-HT1a autoreceptor (somatodendritic?) agonism Abilify exhibits?
> I'm not sure. Does it have any post synaptic efficacy at 5-ht1a?From what I've read, it does. However, I don't know what the net effect on PFC activity would be.
> The acute effects of agonizing 5-ht1a autoreceptors would be to decrease overall serotoninergic firing. This might be expected to increase dopamine release in certain brain regions which are under inhibitory control by serotonin.
Okay. I understand.
> OHOT, chronic administration might desensitize the autoreceptors, thus increasing serotonergic functioning and producing the reverse action.
>
> It really depends on the brain region and the serotonin receptor involved. For instance, in the frontal cortex, post synaptic 5-ht1a agonism increases dopamine release, wheras 5-ht2c agonism decreases it.Interesting.
Thanks for replying.
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but in how hard the climb.The measure of success lies only in how high one feels he must
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poster:SLS
thread:961768
URL: http://www.dr-bob.org/babble/20100908/msgs/961906.html