Posted by conundrum on March 29, 2010, at 22:49:13
In reply to Re: Anhedonia » conundrum, posted by Economist on March 29, 2010, at 22:33:57
I was thinking of waiting for bleauberry to respond, but neither of those drugs are really good indicators of whether you respond to norepinephrine well. Cymbalta is much stronger on serotonin and probably washes out its adrenergic effects. Wellbutrin boosts dopamine weakly and does even less to boost norepinephrine. The names SNRI, DNRI are more marketing tools than indictions of what they do. I'm talking about trying something like Nortriptyline, Protriptyline, or Desipramine. They're fairly selective for norepinephrine.
Take a look at the study below. You can see that both effexor and symbalta bind much more strongly (the smaller number) to the serotonin transporter than norepinephrine. Cymbalta is 7.5 for NE(weaker) and 0.8 for serotonin (stronger).
Bupriopion seems to work on nitric Oxide pathways that is not clearly understood.
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T1J-4NN0WF3-2&_user=10&_coverDate=07%2F30%2F2007&_rdoc=1&_fmt=high&_orig=search&_sort=d&_docanchor=&view=c&_searchStrId=1273803560&_rerunOrigin=google&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=29fda8e917b616a24358232f1a53f9f5If you read you can see that only one of the doses given to the animals in this study increased norepinephrine. Obviously human brains are different.
Maybe I'm totally wrong though and none of what I'm saying matters. Maybe you haven't found the right dopaminergic drug yet or the right dose. But you have tried a number and it would be ashame to miss out on something that might work because you've already made up your mind that only one type of drug will work. I've done the same thing, could be doing it now. Who knows what will work?
Post-SSRI syndrome: iatrogenic anhedonia, memory and concentration problems, sexual dysfunction. [NOTE no sadness or anxiety, this is NOT depression!]
Current med: 100mg pristiq
Location: USA
poster:conundrum
thread:941022
URL: http://www.dr-bob.org/babble/20100328/msgs/941389.html