Posted by conundrum on March 29, 2010, at 22:27:12
In reply to Anhedonia » conundrum, posted by Economist on March 29, 2010, at 21:36:56
Yeh, I mean I didn't have it before taking prozac, but I also didn't have it while on prozac. Just after stopping it. So it could have been the drug causes changes in the brain that don't reverse, or it could have been the quick taper off. Either way, I doubt I would be feeling this way had I never taken prozac since i was mainly anxious before taking it. If I take it now I can only tolerate low doses and it does increase motivation but doesn't change anhedonia. I start doing more things but don't really know why. I'm interested in trying low dose prozac with a TCA or adrafinil.
Maybe you should decrease the amulsipride since at higher doses it blocks the D2 receptors from being activated by dopamine.
Have you considered trying anything adrenergic? Seems like you've done almost all you can with dopaminergic drugs, and haven't given adrenergic drugs a shot.
Another thing that might help similar to low dose prozac is a low dose of an AP that blocks serotonergic receptors, like zyprexa or something in that class. I think the thing that makes low dose prozac helpful for me is it blocks some serotonergic post synaptic receptors. Thats just a theory though.
Post-SSRI syndrome: iatrogenic anhedonia, memory and concentration problems, sexual dysfunction. [NOTE no sadness or anxiety, this is NOT depression!]
Current med: 50mg pristiq
Location: USA
poster:conundrum
thread:941022
URL: http://www.dr-bob.org/babble/20100328/msgs/941385.html