Posted by Marty on August 6, 2008, at 11:30:19
In reply to Re: Fluoxetine = 5-HT2c Potent antagonist ? ..confused, posted by JayBTV2 on August 6, 2008, at 10:20:57
> I don't think 5-ht2c is the problem w/ SSRI sexual side-effects. Based on the fact that the new drug Agomelatine (Valdoxan) is supposed to a 5-ht2c antagonist and it _doesn't_ have the same sexual side-effect issues as most SSRIs.
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Hi, I respect your opinion, but I have to disagree with your rationale. Your logic is flawed because most AD with sexual side effects induce those because they STIMULATE 5-HT2c because of their reuptake inhibiion mecanism of action (more serotonin in the synaptic cleft "pushing buttons" more often.. 5-HT2c receptor being such button).... Agomelatine being a 5-HT2c ANTAGONIST, it REDUCE THE STIMULATION of the 5-HT2c receptor (the button is less frequently pushed).Your logic implying that Agomelatine act the same way on 5-HT2c as the other antidepressants is thus flawed. They act in opposite ways. In fact Agomelatine could be proposed as an antidote for sexual side effect induced by other antidepressants, theorically that is.
That said can't wait for that Agomelatine to be approved. (damn FDA)
/\/\arty
poster:Marty
thread:844424
URL: http://www.dr-bob.org/babble/20080805/msgs/844559.html