Posted by zinya on July 21, 2003, at 12:48:08
In reply to Re: re: dividing granules,Rx to Dr. Bob and/or » zinya, posted by noa on July 20, 2003, at 17:22:39
Greetings to any or all of you,
noa suggested i write a post to your attention to ask any of you what you could tell me about when and how Effexor supposedly begins to affect norepinephrine (adrenal system) levels.
When I first started reading here a few months ago, at least one poster on the board here said that it's only at 150 mg that the second-system effects begin, on the norepinephrine / adrenal system.
I wrote a post once to Dr. Bob for confirmation but a monitor answered saying I'd have to get the answers in "the monograph" allegedly somewhere on the site but I couldn't find a monograph. I wrote back asking for a site address and never got an answer. Do you know where this monograph is? Or could you say more about when and how the adrenal system effects "kick in"?
If I understand from the PDI which I finally got yesterday from the pharmacy, 92% of each dosage goes toward serotonin and only 8% toward norepinephrine. So would that mean that it takes getting up to 150 mg before that 8% becomes a sizeable enough amount to start showing a major effect? And, from what it also says, it's sounds like there's some metabolizing catalyst factor (called CYP2D6) (!?!?) that varies in each of us which could impact somewhat (?) how much each of us might need to take in order to reach that same degree of effectiveness for the norepinephrine 8% ?? Would that be an accurate conclusion to draw?
The impression I'm getting is that perhaps, like everything else with these drugs, the effect probably varies by person and it wouldn't necessarily be at 150mg for each person that the norep. levels would start feeling significant effect.
Anyway, that's my set of questions. Could you offer any knowledge you have about this?
thanks very much,
zinya
poster:zinya
thread:13781
URL: http://www.dr-bob.org/babble/20030718/msgs/243905.html