Posted by SLS on October 31, 2002, at 19:57:13
In reply to Re: Citalopram pharmacology » SLS, posted by dr. dave on October 31, 2002, at 8:26:26
Hi, Dr. Dave.
> > Do you feel you know enough about the brain, physiology, organic chemistry, and the pharmacology of these two drugs to state anything about getting down to science? I admit that I don't (not such a revelation). I just like doing thought experiments - you know - theory. My theories are constructed with great care but with insufficient knowledge for them to be worth a damn.
> The main point I've been trying to make on this board is that claims are being made on very weak evidence about this drug,
I haven't been following the posts closely enough. What are the claims being made? What evidence has been offered to cooraborate these claims? Thanks.
> by which I mean there's no plausible mechanism of action (for any superiority over citalopram) that's been substantiated at all.
How would you critique my hypothesis regarding antagonistic stereochemisty between the enantiomers? How might this relationship be viewed with respect to the actions of partial agonists at neurotransmitter receptors?
> I feel qualified to comment on the science as it's what I've been educated in for many years, and it's my job to have an understanding of it - but I'm only commenting, which is not to say I don't get things wrong sometimes.
What is your background, and how are you applying it today?
I wish I had more. I might be able to help figure out this MF.
Be well.
Sincerely,
Scott
poster:SLS
thread:109458
URL: http://www.dr-bob.org/babble/20021025/msgs/125996.html