Posted by pharmrep on October 9, 2002, at 16:18:08
In reply to Re: Technical questions for Celexa/LexaPro Rep » chad_3, posted by JLM on October 8, 2002, at 22:26:24
> > Hi Sir -
> >
> > This is a 2 part question:
> >
> > 1) Do you believe Celexa is as effective as Paxil across comparable dose ranges, especially for dysthymia, major depression, and general anxiety (all 3 disorders) ... If indeed LexaPro potently blocks s2 and s3 receptors, would this drug not be highly effective in treating certain a host of movement disorders (aka; clozapine)... ?
> >
> > 2) It is now common for urologists to use Paxil to treat premature ejaculators, and for psychiatrists to prescribe Zoloft to tame males who are overly sexually agressive.
>
> Good god, that just shows how totally out of control the practice of medicine has gotten. It seems like SSRI's work for almost anything you would care to prescribe them for. Its also a good
> argument for the non specificity of their effects.
>************* #1 Celexa/Paxil share similar efficacy at the same doses..20mg =20mg/40=40 etc as for the lexapro blocking/cloz question..help me understand what youre asking.
>
> > In your personal opinion, do you believe that LexaPro will be as effective as Paxil (for premature ejactulation / excess libido) and/or as effective as Zoloft for sexual overaggression.************** #2 Since efficacy between ad's was so similar in the past I do know of some dr's who rx on the basis of side effects, but that is not usually the primary reason for choosing a med.
************** #3 In my personal opinion...sexual side effects for ssri's are a class effect, and the one that seems to be the worst is paxil. It is too soon to tell, but Lexapro shouldnt be any worse that celexa. Maybe one day a study will be done to see where they rank among each other.
> >
> > Sincerely,
> > Chad
> >
> >
> > > > The other interesting statement recently has been
> > > >
> > > > ' ...celexa can cause both insomnia and somnolence...usually people are tired...you are doing the right thing in taking early in day, but you still stay up at night. Lexapro doesnt have the somnolence, but a little insomnia for some'
> > > >
> > > > Lundbeck say that 6.9% of people taking Lexapro had somnolence in recent trials, compared to 4.7% in the Celexa group. The difference was not statistically significant. Could you tell us your proof source for the statement that Lexapro 'doesn't have somnolence.'************* Sure, in the PI...Lexapro had 4% somnolence at 10mg & 9% at 20mg, 20mg Celexa had 18%.(ps, the 4.7% above was placebo, not celexa)
> > >
> > > Once again, I too, would like to see something to validate this claim other than the small, statistically insignificant difference between citalopram and escitalopram.
> > >
************ small? There is a "statistically signficant difference" between lexapro and placebo, and the studies didnt have to but did include the higher titrated dose of 40mg of celexa to show the advantage of lexapro, in both efficacy and quicker onset of action. It's still only 1 month out and many more studies are on the way, so keep reading them and let's keep discussing the findings and also sharing any info or questions for those currently taking Lexapro.
poster:pharmrep
thread:109458
URL: http://www.dr-bob.org/babble/20021006/msgs/122950.html