Re: Lexapro side-effects

Posted by Patson on August 19, 2002, at 23:18:08

In reply to Re: Lexapro side-effects » dr. dave, posted by Ritch on June 19, 2002, at 9:11:56

> > Just for accuracy of information... Celexa's patent in the US won't expire until 2003. There is also a six month exclusivity extension due to clinical studies conducted in children. In addition, a generic citalopram would take about 18 months to get approval from the FDA. A generic equivalent for Celexa then wouldn't be available until sometime in 2005.

> > The research shows Lexapro has no significant benefit over Celexa in terms of side-effects. People taking Lexapro 20mg report side-effects at the same rate as those on Celexa 40mg (86%).
> >
> > In the same study more people stopped taking Lexapro 20mg because of side-effects than those taking Celexa 40mg (10.4% vs 8.8%), but this difference was not statistically significant.
> >
> > The reason for this is that Lexapro is to all intents and purposes the same thing as Celexa but re-branded and re-patented. There is no evidence of the R-citalopram component they have removed doing anything of significance pharmacologically. To understand this 'new' drug you have to understand that the patent on Celexa just ran out, but the manufacturers can effectively renew the patent by isolating the active component and re-branding it.
> >
> > See more at http://www.guardian.co.uk/Archive/Article/0,4273,4434943,00.html
> >
> > The critical comments in the article are mine.
>
>
> Hi,
>
> Thanks for the article. It wouldn't surprise me a whole lot if the only advantage it winds up having is less medicine for your liver to clear out! I have always wondered about the "mechanism" versus "medicine" distinction between antidepressants when it comes to how they work and side-effects. SSRI's all tend to cause many similar wanted and unwanted effects. If they isolated the *active* isomer, then they probably isolated something that is *more* likely to cause typical SSRI wanted and *unwanted* effeects. It will be interesting to see the comments made here when people start "reporting" in about it.
>
> Mitch
>

Thread

Anyone switched to Lexapro? « ggrrl Dr. Bob 6/11/02
...
Little higher # on sexual SE, not good. (nm) Phil 8/16/02
Re: sexual s/e Phil » pharmrep Phil 8/16/02
Re: sexual s/e » Phil pharmrep 8/17/02
Re: that Phil, he's a manly hi-T kind of guy ;-) (nm) » Phil .tabitha. 8/17/02
Re: Lexapro is no different from Celexa dr. dave 8/19/02
Re: Lexapro is no different from Celexa » dr. dave Ritch 8/19/02
How do you act on that information? » dr. dave Anyuser 8/19/02
Tangent on Costs shar 8/19/02
Re: Tangent on Costs » shar Anyuser 8/19/02
Re: Lexapro is no different from Celexa » dr. dave johnj 8/19/02
Re: Lexapro is no different from Celexa (I agree) (nm) Maximus 8/19/02
Re: Lexapro is no different from Celexa Patson 8/19/02
Re: Lexapro side-effects Patson 8/19/02
Re: Lexapro side-effects » Patson pharmrep 8/19/02
Re: Lexapro is different » Patson pharmrep 8/20/02
Citalopram pharmacology - Mitch dr. dave 8/20/02
Re: How do you act on that information? dr. dave 8/20/02
Lexapro still isn't different - pharmrep dr. dave 8/20/02
Re: Citalopram pharmacology -Dr. Dave Ritch 8/20/02
Re: Citalopram pharmacology - Mitch » dr. dave pharmrep 8/20/02
Re: Dr, where do you get that information? » dr. dave pharmrep 8/20/02
Prescribing info is up at Lexapro.com (nm) Anyuser 8/20/02
Re: Lexapro is different » dr. dave pharmrep 8/20/02
Re: Citalopram pharmacology -Dr. Dave » Ritch pharmrep 8/20/02
Question re dose » pharmrep Anyuser 8/20/02
...
Re: Anyone switched to Lexapro? » lil jimi lil jimi 9/8/16

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