![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by mav27 on January 5, 2009, at 1:41:23
Just wanted to gather some info here.... from research people may have done themselves ect into it rather than just running into the normal websites i come accross with google. What are the thoughts on what causes adhd in the brain and why do stimulants seem to solve the problem when they sound as though they would make a hyper active kid more hyperactive. Does dexedrine do more than just release more DA and NE ?
Posted by desolationrower on January 9, 2009, at 17:01:41
In reply to What are the current thoughts on ADHD causes, posted by mav27 on January 5, 2009, at 1:41:23
hm, i looked into this, didn't read enough or remember enough for a complete picture. i don't think its well understood yet...generally both environmental factors like exposure to nicotine as a foetus, general stressors while young, as well as some genetic things relating to the catecholamines...
stimulants help, by na & da activating some inhibitory receptors, thus increasing signal to noise ratio, improving prefrontal coherence and increasing tonic activity of catecholamines and so proloning time one can hold goal in mind and pursue it before requiring a rewrad or terminating effort, also improving learning of no-longer-rewarded activities so one can change and adapt to new context. inhibitory d2 probably more important in striatum as for reducing hyperactiveness. d1 in pfc for direct activity, i think basal ganglia input also is important. alpha 2, especially alpha2a activation is important in pfc, but alpha1 tend to result in overfocus.
-d/r
there is some difference in how methylphenidate, amp, and nris work too
Posted by mav27 on January 10, 2009, at 20:13:35
In reply to Re: What are the current thoughts on ADHD causes, posted by desolationrower on January 9, 2009, at 17:01:41
Very interesting, thanks. Do you know of any anti-psychotics that will block dopamine receptors in the prefrontal area but not ( or at least a lot less than) in the striatum area ?
> hm, i looked into this, didn't read enough or remember enough for a complete picture. i don't think its well understood yet...generally both environmental factors like exposure to nicotine as a foetus, general stressors while young, as well as some genetic things relating to the catecholamines...
>
> stimulants help, by na & da activating some inhibitory receptors, thus increasing signal to noise ratio, improving prefrontal coherence and increasing tonic activity of catecholamines and so proloning time one can hold goal in mind and pursue it before requiring a rewrad or terminating effort, also improving learning of no-longer-rewarded activities so one can change and adapt to new context. inhibitory d2 probably more important in striatum as for reducing hyperactiveness. d1 in pfc for direct activity, i think basal ganglia input also is important. alpha 2, especially alpha2a activation is important in pfc, but alpha1 tend to result in overfocus.
>
> -d/r
>
> there is some difference in how methylphenidate, amp, and nris work too
Posted by desolationrower on January 11, 2009, at 2:26:42
In reply to Re: What are the current thoughts on ADHD causes » desolationrower, posted by mav27 on January 10, 2009, at 20:13:35
> Very interesting, thanks. Do you know of any anti-psychotics that will block dopamine receptors in the prefrontal area but not ( or at least a lot less than) in the striatum area ?
>
> > hm, i looked into this, didn't read enough or remember enough for a complete picture. i don't think its well understood yet...generally both environmental factors like exposure to nicotine as a foetus, general stressors while young, as well as some genetic things relating to the catecholamines...
> >
> > stimulants help, by na & da activating some inhibitory receptors, thus increasing signal to noise ratio, improving prefrontal coherence and increasing tonic activity of catecholamines and so proloning time one can hold goal in mind and pursue it before requiring a rewrad or terminating effort, also improving learning of no-longer-rewarded activities so one can change and adapt to new context. inhibitory d2 probably more important in striatum as for reducing hyperactiveness. d1 in pfc for direct activity, i think basal ganglia input also is important. alpha 2, especially alpha2a activation is important in pfc, but alpha1 tend to result in overfocus.
> >
> > -d/r
> >
> > there is some difference in how methylphenidate, amp, and nris work too
>
>hm no that sounds like a bad idea though?
-d/r
Posted by mav27 on January 11, 2009, at 4:02:27
In reply to Re: What are the current thoughts on ADHD causes, posted by desolationrower on January 11, 2009, at 2:26:42
> > Very interesting, thanks. Do you know of any anti-psychotics that will block dopamine receptors in the prefrontal area but not ( or at least a lot less than) in the striatum area ?
> >
> > > hm, i looked into this, didn't read enough or remember enough for a complete picture. i don't think its well understood yet...generally both environmental factors like exposure to nicotine as a foetus, general stressors while young, as well as some genetic things relating to the catecholamines...
> > >
> > > stimulants help, by na & da activating some inhibitory receptors, thus increasing signal to noise ratio, improving prefrontal coherence and increasing tonic activity of catecholamines and so proloning time one can hold goal in mind and pursue it before requiring a rewrad or terminating effort, also improving learning of no-longer-rewarded activities so one can change and adapt to new context. inhibitory d2 probably more important in striatum as for reducing hyperactiveness. d1 in pfc for direct activity, i think basal ganglia input also is important. alpha 2, especially alpha2a activation is important in pfc, but alpha1 tend to result in overfocus.
> > >
> > > -d/r
> > >
> > > there is some difference in how methylphenidate, amp, and nris work too
> >
> >
>
> hm no that sounds like a bad idea though?
>
> -d/rMy reasoning is that prozac supposedly leads to increased dopamine in the prefrontal cortex through 5ht2c antagonism... and the stuff is driving me bonkers(worsening my temper outburts/rage) But studies seem to be showing that social phobia which i'm diagnosed with may be in part due to decreased binding of d2 in the striatum.
This is the end of the thread.
Psycho-Babble Neurotransmitters | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.