Posted by mav27 on January 10, 2009, at 20:13:35
In reply to Re: What are the current thoughts on ADHD causes, posted by desolationrower on January 9, 2009, at 17:01:41
Very interesting, thanks. Do you know of any anti-psychotics that will block dopamine receptors in the prefrontal area but not ( or at least a lot less than) in the striatum area ?
> hm, i looked into this, didn't read enough or remember enough for a complete picture. i don't think its well understood yet...generally both environmental factors like exposure to nicotine as a foetus, general stressors while young, as well as some genetic things relating to the catecholamines...
>
> stimulants help, by na & da activating some inhibitory receptors, thus increasing signal to noise ratio, improving prefrontal coherence and increasing tonic activity of catecholamines and so proloning time one can hold goal in mind and pursue it before requiring a rewrad or terminating effort, also improving learning of no-longer-rewarded activities so one can change and adapt to new context. inhibitory d2 probably more important in striatum as for reducing hyperactiveness. d1 in pfc for direct activity, i think basal ganglia input also is important. alpha 2, especially alpha2a activation is important in pfc, but alpha1 tend to result in overfocus.
>
> -d/r
>
> there is some difference in how methylphenidate, amp, and nris work too
poster:mav27
thread:872322
URL: http://www.dr-bob.org/babble/neuro/20080706/msgs/873242.html