Psycho-Babble Alternative Thread 412115

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Inosine?

Posted by Larry Hoover on November 5, 2004, at 11:24:20

Anybody ever used it?

Lar

Re: Inosine? » Larry Hoover

Posted by sunny10 on November 5, 2004, at 13:02:16

In reply to Inosine?, posted by Larry Hoover on November 5, 2004, at 11:24:20

Is there a "common name" ?

Re: Inosine? » sunny10

Posted by Larry Hoover on November 5, 2004, at 13:36:44

In reply to Re: Inosine? » Larry Hoover, posted by sunny10 on November 5, 2004, at 13:02:16

> Is there a "common name" ?

That is the common name. It's a natural intermediate in RNA synthesis, ATP formation, but also has regulatory effects. It suppresses interleukins, and mops up peroxynitrite. It's an over the counter supplement.

http://www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/ino_0144.shtml

It sounds like it almost can't have an adverse effect, unless you're prone to gout, or uric acid kidney stones.

Lar

Re: Inosine?- guess I've never tried it then! (nm) » Larry Hoover

Posted by sunny10 on November 5, 2004, at 14:29:27

In reply to Re: Inosine? » sunny10, posted by Larry Hoover on November 5, 2004, at 13:36:44

Re: Inosine? » Larry Hoover

Posted by raybakes on November 7, 2004, at 5:27:40

In reply to Re: Inosine? » sunny10, posted by Larry Hoover on November 5, 2004, at 13:36:44

>
> It sounds like it almost can't have an adverse effect, unless you're prone to gout, or uric acid kidney stones.
>
Hi Lar, sounds interesting! How do you think it might affect the second messenger cAMP? and how might that affect dopamine receptors?

Also heard that adenosine excess can be linked with excitotoxicity - how would inosine affect adenosine in that circumstance?

'Adenosine and glutamate extracellular concentrations and mitogen-activated protein kinases in the striatum of Huntington transgenic mice. Selective antagonism of adenosine A2A receptors reduces transmitter outflow.'

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15350968

Ray

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