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Re: Inosine? » Larry Hoover

Posted by raybakes on November 7, 2004, at 5:27:40

In reply to Re: Inosine? » sunny10, posted by Larry Hoover on November 5, 2004, at 13:36:44


>
> It sounds like it almost can't have an adverse effect, unless you're prone to gout, or uric acid kidney stones.
>
Hi Lar, sounds interesting! How do you think it might affect the second messenger cAMP? and how might that affect dopamine receptors?

Also heard that adenosine excess can be linked with excitotoxicity - how would inosine affect adenosine in that circumstance?

'Adenosine and glutamate extracellular concentrations and mitogen-activated protein kinases in the striatum of Huntington transgenic mice. Selective antagonism of adenosine A2A receptors reduces transmitter outflow.'

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15350968


Ray



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