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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 12 of 12. This is the beginning of the thread.
Posted by uncouth on February 5, 2009, at 11:48:25
Hi,
My doctor called me out of the blue yesterday, my second day of rTMS treatments (a shorter course than the full course I went through in October) to tell me he's calling in an Rx for Deplin 7.5mg.He's never done this before so I figure he must think it's an interesting addition to my meds and that it may have some effect on me. I've been treatment resistant to a variety of ADs and augmentors, the best i've ever gotten is partial response (taking away suicidal thoughts) but never an increase in the reduced positive affect side of things.
I'm curious if anyone is currently on Deplin, and what their experiences have been. I did a search through the archives and it looks like people have had varied responses. Specifically, how long does it typically take to work, if it does, and if anyone is Bipolar 2, has deplin ever triggered a hypomania?
Thanks for any information you can provide on L-methylfolate (deplin)
Posted by Phillipa on February 5, 2009, at 13:13:49
In reply to Deplin (L-methylfolate) questions, posted by uncouth on February 5, 2009, at 11:48:25
Hey maybe Scott will share his experiences. I also took it for two weeks third day felt better faded was told could should might respond. I only took it for two weeks as was cash for me. Good luck it can't hurt you I don't think but I'm not bipolar II. Love Phillipa
Posted by SLS on February 5, 2009, at 14:07:04
In reply to Deplin (L-methylfolate) questions, posted by uncouth on February 5, 2009, at 11:48:25
> Hi,
> My doctor called me out of the blue yesterday, my second day of rTMS treatments (a shorter course than the full course I went through in October) to tell me he's calling in an Rx for Deplin 7.5mg.Interesting. He must be having some success with it. Or perhaps there is some new finding the rTMS will work better with it.
> He's never done this before so I figure he must think it's an interesting addition to my meds and that it may have some effect on me.
What drugs are you currently taking?
> I've been treatment resistant to a variety of ADs and augmentors, the best i've ever gotten is partial response
On which drugs? How would you describe a "partial response"?
> I'm curious if anyone is currently on Deplin, and what their experiences have been.
I was on Deplin for a number of months. I added to Nardil and nortriptyline. I felt an improvement during the first week that faded. After a few more weeks, I experienced a major improvement from Deplin. The thing is, the improvement faded gradually until I was left with nothing but nightmares. If you start getting nightmares of otherwise vivid dreams, I would suggest an experiment to cut the dosage in half. I hadn't thought to do that at the time. Maybe it would have kept working if I hadn't allowed the levels to build up so high.
Can Deplin induce a manic reaction? I'm not sure. Hell, if fish oil can do it, I wouldn't know of anything that would exclude Deplin from have such potential.
Do it. You have nothing to lose. No side effects for me except the eventual appearance of dreaming abnormalities.
Good luck!
- Scott
Posted by uncouth on February 5, 2009, at 14:22:08
In reply to Re: Deplin (L-methylfolate) questions » uncouth, posted by SLS on February 5, 2009, at 14:07:04
Thanks.
I'm currently on: pristiq 100mg, lithium 300mg, abilify 7.5mg, seroquel 50mg, agomelatine 25mg, adderall 10mg 2x day, deprenyl 5mg 2x week for MAO-B inhibition and it's antioxidant effects. doctor doesn't know about deprenyl and agomelatine as i'm sure he wouldn't be able to recommend it for professional liability reasons, and i dont want to get him mad at me.
Partial response is remission of suicidal/obsessive thoughts, but no increase in positive affect, or self-esteem/confidence/motivation.
I've been on a bunch of stuff before...typical laundry list including emsam, nardil, and parnate. MAOIs worked but i'd keep on having to push up the dose and emsam made me a bit hypomanic, nardil had too many side effects, parnate was the best of them but had to keep pushing the dose higher and higher and it never was stimulating enough to kill the ADHD symptoms. did a course of 20 rTMS sessions in october which helped a bit for a few weeks after. now going back for a shorter course. just started pristiq 2 weeks ago so it hasn't perhaps kicked in quite enough yet, but so far at 100mg it doesn't feel nearly as effective as effexor was at 300mg, so i may switch back to that. can't say anything regarding the agomelatine, been taking in for 2 months now (though i haven't told my doctor) and while it seems to help with sleep, it hasn't resolved the depression. i'll stick with it as it may work differently with pristiq than it did with parnate, and it doesnt seem to have any interaction effects.
also take a bunch of supplaments including b vitamins, NAC, fish oil, 7-keto, DLPA
Thanks, i'll watch out for dreaming issues.
Posted by theo on February 8, 2009, at 14:32:51
In reply to Deplin (L-methylfolate) questions, posted by uncouth on February 5, 2009, at 11:48:25
As Scott mentioned, watch out for violent dreams. I actually tried this with no other meds as to isolate if the violent dreams were coming from Deplin or another med, it was the Deplin.
I felt a moment of clarity about the second day I took it and that was it, no benefits for me.
Posted by Cady on February 10, 2009, at 5:49:43
In reply to Deplin (L-methylfolate) questions, posted by uncouth on February 5, 2009, at 11:48:25
> I'm curious if anyone is currently on Deplin, and what their experiences have been. I did a search through the archives and it looks like people have had varied responses. Specifically, how long does it typically take to work, if it does, and if anyone is Bipolar 2, has deplin ever triggered a hypomania?
>
I experienced mild hypomania a few days after starting Deplin, so I stopped it just in case. I tried it a couple more times after that for a few days each time, and no hypomania, but some mood instability, either more frequent swings or a mixed quality to my moods. I'm not positive it was the Deplin, but I'm not trying it again. I tried it because I take Lamictal and was having cognitive problems. Thought it might be folate depletion.
Posted by NewQuestions on February 12, 2009, at 9:51:23
In reply to Deplin (L-methylfolate) questions, posted by uncouth on February 5, 2009, at 11:48:25
Where are you getting TMS treatments? Is it helping?
Posted by uncouth on February 12, 2009, at 9:53:55
In reply to Re: Deplin (L-methylfolate) questions--uncouth, posted by NewQuestions on February 12, 2009, at 9:51:23
from a doctor in the palo alto area.
can't say i'm getting remission due to rTMS unfortunately. i went through a course of 19 sessions in october and i think it helped, but it wasn't a cure. i did end up getting an 800 on my verbal section of the GRE though, so i think it did something positive to my brain :)
its hard for me to isolate what's responsible for response since i was adding abilify at the same time, and now i'm going up one ffexor at the same time doing the additional sessions.
Posted by NewQuestions on February 12, 2009, at 10:18:08
In reply to Re: Deplin (L-methylfolate) questions--uncouth, posted by uncouth on February 12, 2009, at 9:53:55
I am thinking about doing it but my drug history is different. I took an SSRI for years, then my body adapted to it, the drug pooped out, I tried to take others but became hypersensitive to all of them, and not am forced to go off all drugs. I just can't tolerate them anymore--they make me worse, not better.
Given the change in my body, I am wondering whether TMS is the solution. I worry that it is like sending electricity through a wire--if the wire is functioning, it works, but if there is something wrong with the wire, it will blow it out.
Posted by herpills on February 12, 2009, at 12:59:06
In reply to Re: Deplin (L-methylfolate) questions, posted by Cady on February 10, 2009, at 5:49:43
Hi Cady,
I am also taking Lamictal and have been reading up on Deplin. Did doctor do test for folate?
Is anyone taking Lamictal+Deplin combo? Website says it's augmentation for antidepressants, do they mean just ssri meds?
herpills
> I experienced mild hypomania a few days after starting Deplin, so I stopped it just in case. I tried it a couple more times after that for a few days each time, and no hypomania, but some mood instability, either more frequent swings or a mixed quality to my moods. I'm not positive it was the Deplin, but I'm not trying it again. I tried it because I take Lamictal and was having cognitive problems. Thought it might be folate depletion.
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Posted by Phillipa on February 12, 2009, at 19:26:00
In reply to Re: Deplin (L-methylfolate) questions » Cady, posted by herpills on February 12, 2009, at 12:59:06
Herpills no it's also been used with other classes of ad's. I took it for two weeks and stopped was having surgery at time and didn't want to risk skewing results of any blood work that might be done. Day three did feel better and that was it. Was on SSRI and benzo at time. Phillipa
Posted by Gennysmom on March 4, 2009, at 14:14:20
In reply to Re: Deplin (L-methylfolate) questions » SLS, posted by uncouth on February 5, 2009, at 14:22:08
I took antidepressant meds for 30 years with a partial response to several. I have taken over the counter B supplements without much improvement. In April of 08 I began taking Deplin. I felt better within a few days. I now have relief from the depression. I have not experienced any manic swing, either. I take Wellbutrin, Pristiq, Lamical and Gabapentin. There doesn't seem to be a problem with interactions for me.
This is the end of the thread.
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