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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 8 of 8. This is the beginning of the thread.
Posted by ben on May 21, 2005, at 9:53:17
Hi
Does anyone have experiences with the combination of Venlafaxine with Moclobemide ? I am on 450 mg of Effexor, Lithium, Neurontin 800 mg twice daily. Effexor pooped out at 225 mg and didnt give me relief on 450 mg. 2 weeks ago I added Remeron (gradualy up to 45 mg). My mood is still bad and I think it is worser than with 200 mg of Trazodone (Desyrel). Now I think of going of the Remeron and adding Moclobemide (idea of my pdoc). Or should I wait with the Remeron or perhaps going back (directly) to Desyrel.
I read on pubMed that early onset of relief predicts the outcome of response and remisson for Remeron and that only a subtype of the catechol-o-methyltransferase (COMT) population develop response on Remeron. Perhaps I have not that kind of COMT???
Posted by The Resistance on May 21, 2005, at 15:36:57
In reply to Venlafaxine (Effexor) and Moclobemide (Manerix) ?, posted by ben on May 21, 2005, at 9:53:17
Hey Ben I'm afraid I had a bad experience combining Effexor with Moclebemide a few months ago.
I added a very low dose of Moc (50mg) to my 150mgs of Effexor.
Initially it stimulated me, but then I felt tired, it also caused a lot of anxiety/agitation.I don't think there's much risk of developing seratonin syndrome on this combination as long as your very careful.
Mocs not like an ireversible MAOI (sadly)I remeber reading a report a long time ago on this board, by someone who did have success on this combination.
The thing about Remeron and COMPT is really interesting, I seem to respond well to Remeron.
Posted by Phillipa on May 21, 2005, at 18:04:30
In reply to Re: Venlafaxine (Effexor) and Moclobemide (Manerix) ?, posted by The Resistance on May 21, 2005, at 15:36:57
What is COMPT? Fondly, Phillipa
Posted by SLS on May 21, 2005, at 21:13:18
In reply to Venlafaxine (Effexor) and Moclobemide (Manerix) ?, posted by ben on May 21, 2005, at 9:53:17
Hi.
Effexor is a very potent serotonin reuptake inhibitor. I would recommend caution when combining it with moclobemide, despite the reversibility of MAO activity allowed for by moclobemide. I'm sure you are aware of the of risk of developing serotonin syndrome (SS) when combining SRI antidepressants and MAOIs. I feel that there are enough reports on Medline of adverse reactions when moclobemide is combined with a SRI to warrant a careful titration of medication and an understanding of what symptoms to look for that would be indicative of SS. You might want to keep some cyproheptadine at hand in case the syndrome emerges. These are things best discussed with your doctor.
Has your doctor ever combined moclobemide with SRIs before?
- Scott
Posted by ben on May 22, 2005, at 1:58:31
In reply to Re: Venlafaxine (Effexor) and Moclobemide (Manerix) ? » The Resistance, posted by Phillipa on May 21, 2005, at 18:04:30
> What is COMPT? Fondly, Phillipa
read this:
Posted by ben on May 22, 2005, at 2:00:01
In reply to Re: Venlafaxine (Effexor) and Moclobemide (Manerix) ? » ben, posted by SLS on May 21, 2005, at 21:13:18
> Hi.
>
> Effexor is a very potent serotonin reuptake inhibitor. I would recommend caution when combining it with moclobemide, despite the reversibility of MAO activity allowed for by moclobemide. I'm sure you are aware of the of risk of developing serotonin syndrome (SS) when combining SRI antidepressants and MAOIs. I feel that there are enough reports on Medline of adverse reactions when moclobemide is combined with a SRI to warrant a careful titration of medication and an understanding of what symptoms to look for that would be indicative of SS. You might want to keep some cyproheptadine at hand in case the syndrome emerges. These are things best discussed with your doctor.
>
> Has your doctor ever combined moclobemide with SRIs before?
>
>
> - Scott
Hi Scotthe did it with others.
ben
Posted by SLS on May 22, 2005, at 7:23:53
In reply to Re: Venlafaxine (Effexor) and Moclobemide (Manerix) ? » SLS, posted by ben on May 22, 2005, at 2:00:01
> > Hi.
> >
> > Effexor is a very potent serotonin reuptake inhibitor. I would recommend caution when combining it with moclobemide, despite the reversibility of MAO activity allowed for by moclobemide. I'm sure you are aware of the of risk of developing serotonin syndrome (SS) when combining SRI antidepressants and MAOIs. I feel that there are enough reports on Medline of adverse reactions when moclobemide is combined with a SRI to warrant a careful titration of medication and an understanding of what symptoms to look for that would be indicative of SS. You might want to keep some cyproheptadine at hand in case the syndrome emerges. These are things best discussed with your doctor.
> >
> > Has your doctor ever combined moclobemide with SRIs before?
> >
> >
> > - Scott
>
>
> Hi Scott
>
> he did it with others.
>
> ben
>
That is exciting indeed. I wish I didn't have such an intense exacerbation of my depression with moclobemide or I would consider the combination myself. I wish you luck with it. It sounds like a potent combination.
- Scott
Posted by darkhorse on May 24, 2005, at 6:27:51
In reply to Venlafaxine (Effexor) and Moclobemide (Manerix) ?, posted by ben on May 21, 2005, at 9:53:17
I had very bad reaction combining :
Venlafaxine 75 + Moclobemide 150.
Citalopram 20 + Moclobemide 150.But, there was absoluotly no problem combining :
Fluvoxamine 50 + Moclobemide 150.
Fluoxetine 20 + Moclobemide 300.Don't ask me why, because I do not know!!
But only thing I'm sure of is that Moclobemide did nothing !Best wishes,
Darkhorse
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