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Dr. Bob is Robert Hsiung, MD,
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Posted by Jack Smith on May 19, 2003, at 16:06:28
Is Remeron the only US approved antidepressant med thats principal method of action is to act as an agonist of seratonin and norepinephrine sites? It seems like all other non-MAOI drugs inhibit the reuptake of seratonin and norepinephrine. And how exactly does an agonist work? Does it just cause receptors to release more seratonin/ne?
JACK
Posted by SLS on May 19, 2003, at 16:26:08
In reply to Seratonin/NE Agonists, Is Remeron the only one?, posted by Jack Smith on May 19, 2003, at 16:06:28
> Is Remeron the only US approved antidepressant med thats principal method of action is to act as an agonist of seratonin and norepinephrine sites?
Hi Jack.
The major metabolite of Buspar (buspirone) acts the same way Remeron does at NE alpha-2 presynaptic autoreceptors. Buspar itself is a 5-HT1a partial agonist.
- Scott
Posted by SLS on May 19, 2003, at 16:28:51
In reply to Re: Seratonin/NE Agonists, Is Remeron the only one?, posted by SLS on May 19, 2003, at 16:26:08
Most likely, gepirone, a compound related to buspirone, will be approved for depression soon. It, too, has a metabolite that is an antagonist of NE alpha-2 receptors and is itself a 5HT1a agonist. I'm not sure what else it does, but it shouldn't affect DA receptors the same way buspirone does.
- Scott
This is the end of the thread.
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