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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 9 of 9. This is the beginning of the thread.
Posted by Caleb462 on May 6, 2003, at 4:29:01
I've done some searching, but haven't really found anything. I'm trying to find out at what dose effexor begins to inhibit dopamine uptake and to what extent? If it's of any clinical signifgance?
Posted by jrbecker on May 7, 2003, at 10:36:22
In reply to Anybody got any good links- Effexor and dopamine?, posted by Caleb462 on May 6, 2003, at 4:29:01
Posted by jack smith on May 7, 2003, at 13:01:16
In reply to Re: Anybody got any good links- Effexor and dopamine?, posted by jrbecker on May 7, 2003, at 10:36:22
> http://biopsychiatry.com/venlafaxine.html
I'm sorry but I didn't fully understand that abstract. Does it say that the higher the dose of Effexor the more it affects norepinephrine and dopamine but it starts to not affect seratonin? Also, what does it mean when it says that Effexor differs from TCA's because Effexor has no affinity for neurotransmitter sites?
Finally, does Effexor EVER have a significant effect on dopamine?
Posted by Caleb462 on May 7, 2003, at 15:23:40
In reply to Questions by a layman? » jrbecker, posted by jack smith on May 7, 2003, at 13:01:16
>Also, what does it mean when it says that Effexor differs from TCA's because Effexor has no affinity for neurotransmitter sites?
TCAs block certain receptors in the brain, such as chollinergic and histaminic receptors. Effexor does not.
Posted by delna on May 11, 2003, at 15:49:53
In reply to Re: Questions by a layman?, posted by Caleb462 on May 7, 2003, at 15:23:40
This is an interesting article about TCA's versus the newer drugs
http://www.psychiatrist.com/pcc/brainstorm/br5808.htm
hope it is useful
delna
Posted by Willow on May 12, 2003, at 7:38:21
In reply to Re: Questions by a layman?, posted by delna on May 11, 2003, at 15:49:53
Effexor and mirapex both affect dopamine. Am I correct? Do they both have the same affect?
Wondering Willow
Posted by Caleb462 on May 13, 2003, at 3:13:34
In reply to Dopamine?, posted by Willow on May 12, 2003, at 7:38:21
> Effexor and mirapex both affect dopamine. Am I correct? Do they both have the same affect?
>
> Wondering WillowThey both have dopaminergic mechanisms, but the mechanisms are totally different. Effexor blocks dopamine reuptake, but it does so very weakly. Effexor's effect on dopamine is not very signifigant, except for MAYBE at the highest doses.
Mirapex, on the other hand, is a direct agonist of dopamine receptors - meaning it activates the same receptors in the brain that dopamine itself does.
Mirapex is a much more dopamine-oriented drug than Effexor.
Posted by Willow on May 14, 2003, at 8:34:10
In reply to Re: Dopamine?, posted by Caleb462 on May 13, 2003, at 3:13:34
So if I had a negative reaction on my mood from mirapex, upping the doseage of effexor I shouldn't be scared of the same thing happening? And what is a high dose of effexor? Started off with 37.5 2X daily, the XR version, now at 225 daily. Psychiatrist had recently wanted to get up to 300, but I think she got turned off by the side-effects I was having, which to me were fine considering the trade off of positives I was getting. Ugh, here I start rambling.
Thanks for your help.
Willow
Posted by bookgurl99 on May 14, 2003, at 9:06:13
In reply to Re: Dopamine?, posted by Caleb462 on May 13, 2003, at 3:13:34
> Effexor blocks dopamine reuptake, but it does so very weakly. Effexor's effect on dopamine is not very signifigant, except for MAYBE at the highest doses.
Do you know if Serzone has a similar mechanism. I thought it was an SSNRI, but my pdoc said I'm mistaken.
This is the end of the thread.
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