Posted by SLS on December 28, 2009, at 16:03:22
In reply to Re: Why would desipramine's effect on sleep change?, posted by mtdewcmu on December 18, 2009, at 4:55:03
> Another possibility is that perhaps tolerance occurs to the various effects of desipramine at different rates. Maybe you have developed a tolerance to the anti-histamine effect of desipramine, but not the pro-norepinphrine or pro-serotonin effect.
That sounds logical.
It could also be the result of an initial appearance and subsequent disappearance of noradrenergic neuronal accommodation in response to excess synaptic norepinephrine. The accommodation of NE neurons would produce sedation. The downregulation of postsynaptic receptors would reduce this effect and perhaps produce greater alertness. This should take 2-3 weeks.
* Neuronal accommodation is a condition in which a neuron stops firing as the result of excessive membrane excitation and persistent partial depolarization.
- Scott
poster:SLS
thread:927870
URL: http://www.dr-bob.org/babble/neuro/20091104/msgs/931276.html