Posted by bleauberry on May 10, 2008, at 20:13:34
In reply to Zolft helps OCD but doesn't help depression, posted by John Doughboy on May 10, 2008, at 18:04:51
I agree with you that it sounds like a norepinephrine and/or dopamine component that is missing. The difficult part is finding out what drug is going to work for that. There are many, but it is the exact mechanism, not the general assumption of what the drug does, that determines whether it works for any particular person or not. There is no predicting.
The most common choice would be wellbutrin. It made me profoundly worse when added to zoloft, but for other people it works fabulous. Other drugs that in my opinion should be on your radar screen are...
Adderall again except this time add Memantine to it to prevent the tolerance.
Zyprexa
Risperdal
Abilify
Nortriptyline
Desipramine
Duloxetine 30mg added to zoloft, but starting with custom doses of 1/4 capsules (not a common mixture, but at other forums it has been done with good results)
PramipexoleMailorder from overseas:
Trivastal
Adrafinil
MilnacipranNatural arena:
Tyrosine (natural precursor to norepinephrine and dopamine)All of these interact with norepinephrine and dopamine, but in varying mechanisms.
No matter what you try, be prepared to move on and try something else on the list if the first couple or three choices prove negative for you in some way. Keep the chin up and the eye on the goal.
While you mentioned effexor, it does have some norepinephrine and dopamine mechanisms at higher doses, but I just don't like that idea at this point. Zoloft is working for OCD. Half the battle is already won. I would keep that victory and don't mess with it. You may never get it back if you let it go. Happens a lot. Keep zoloft steady and add other things to it. Just my opinions.
poster:bleauberry
thread:828365
URL: http://www.dr-bob.org/babble/neuro/20080418/msgs/828387.html