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Luvox's Effect On the 3A4 System For Metabolism

Posted by bulldog2 on January 31, 2008, at 14:56:24

I recently had my thyroid tested and found all my values had increased quite a bit without increasing my synthroid. I was baffled until I found this writeup by a Dr. Jones. Of course i'm now wondering what other hormones Luvox might effect. Is it increasing testosterone, estradiol etc.?

See Dr. Jones comment below on luvox

Answer: I wouldnt say Im down on Luvox. I do have a few patients who seem to do well on it. The reason I try other serotonin reuptake inhibitors is that Luvox has the most drug-drug interactions in that group of meds (Prozac, Zoloft, Paxil, Celexa, Lexapro, low dose Effexor XR 37.5-75). For example, Luvox blocks the metabolism of caffeine which may be the reason it causes more insomnia. It can cause more daytime sedation. It also blocks the metabolism of all the meds (and hormones) in the 3A4 category (the biggest group), so that can make things very complicated.

 

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poster:bulldog2 thread:809941
URL: http://www.dr-bob.org/babble/neuro/20080114/msgs/809941.html