Posted by FrequentFryer on January 15, 2008, at 21:55:02 [reposted on January 16, 2008, at 2:37:27 | original URL]
In reply to , posted by on December 31, 1969, at 18:00:00
> > Yep your wrong I can guarentee you yellow grapfruit juice increase's some benzo effects.
>
> What am I wrong about? I agreed that grapefruit juice increases blood levels of some benzodiazepines. Like diazepam. That's a scientific fact. But it doesn't effect lorazepam in the slightest. That's also a scientific fact. Then I said I wasn't sure about temazepam and clonazepam. Someone else said temazepam (That's what you were asking about originally) wasn't affected by grapefruit, LarryHoover I believe. Then I made a joke that the placebo effect had been ruined. (The joke was emphasized by the ":)" smiley face symbol). Sorry if this offended you.
>
> It looks like if a benzo is metabolized by the liver, via the CYP3A4 enzyme, then grapefruit will increase it's effects. If it is NOT CYP3A4 metabolized, then grapefruit juice will do absolutely nothing. Like in the case of Lorazepam, or Temazepam (The one you were interested in), grapefruit juice has no effect. So show me where I'm wrong. I'm always learning, and I think I summed this up correctly, but everyone makes mistakes, right?
>
> Phoenix1
Yeah sory I 100% agree with you, (respect your neurological pharmacological knowlege :)). (needed that answer), and Im not a crazy cracker but I thought someone said. So we agree that grapefruit juice has no effect." or something.
(But I went over the previous posts quickly a bit but couldn't find it) so I dunno maybe I was tripping, it's just this messageboard is extremly outdated \ non user friendly and confusing, (Im in IT... But it dose the job) maybe Bob could afford to give me some $$ to make the site looking nice and easy to use.
poster:FrequentFryer
thread:806889
URL: http://www.dr-bob.org/babble/neuro/20080114/msgs/806913.html