Posted by Larry Hoover on March 10, 2007, at 13:56:12
In reply to Re: can you really hurt yourself with high vitamin B6? » Larry Hoover, posted by Franz on March 9, 2007, at 13:18:46
> > > i am very interested in the akathisia studies on pubmed that used 1200mg/day. i am worried however, another pubmed study said that high B6 damaged rat brains (and wasn't actually super high per kg it seemed.) the term "nerve damage" is thrown around a lot in reference to B6 but then so is "reversible". what's the real story?
> >
> > The neuropathy develops due to two factors, dose and duration. An acute treatment (say, a few weeks) at a high dose will likely have a substantially lesser neuropathy risk than the same dose over a year. Everything I've read suggests that all neuropathy symptoms are reversible upon cessation of the B6, in any case.
>
>
> larry. I think he/she is talking about the B6 cortical toxicity, not peripheral. Sorry I don´t have a link at hand.Sorry, I seem to have missed that point. Are you thinking of this: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16201314?
It is correct, that is a rather low exposure, but what exactly is meant by "was injected to"? One doesn't inject B6. It's pretty hard to draw any meaningful conclusions from this paper. Perhaps, one shouldn't inject rats with B6? Injection would bypass the entire first-pass metabolism, and its protective role against overexposure of any sort.
Getting back to the original question, the high-dose B6 treatment of akathisia was short-term. I'd be more concerned with the akathisia than the possible risk of the B6.
Lar
poster:Larry Hoover
thread:736055
URL: http://www.dr-bob.org/babble/alter/20070201/msgs/739883.html