Posted by djmmm on January 21, 2007, at 7:57:02 [reposted on January 21, 2007, at 16:36:51 | original URL]
In reply to PEA with selegiline(Emsam) is dangerous, posted by danr49 on January 20, 2007, at 16:42:25
> I know this technically is supposed to go to the alternative board, but I don't know how many people actually read there. And I know many people are experimenting with this, so I'm posting on this board because it's important:
>
> When you take phenylethylamine (PEA) with an MAOI, there's going to be a pressor dosage where the PEA will start to increase blood pressure and this dosage is likely < 50mg, due to norepinhephrine release just as with tyramine ingestion. After the pressor dosage is reached, even small amounts of increase over this amount will equate to substantial increase in blood pressure.
>
> This can lead to hypertensive crisis that may cause stroke, death, etc.
>
> The studies used carefully controlled dosages of a cap of not more than 20mg at a time given a few times daily.
>
> Just 50mg (maybe less) at once while on an MAOI may cause a significant rise in blood pressure, and once you go much above this you're talking about hypertensive crisis and the possibility of dropping over dead. All it would take is mistakingly measuring out the powder wrong or something.
>
> In other words, I would strongly recommend not doing this.
>
>I agree that the "Hypertensive episode" warning does extend to the Selegiline/PEA combo.
This warning should be included in the MAOI/stimulant category-- that being said, At most conventional doses, the two can be safely combined (many people safely combine MAOIs with other medications)
It must also be noted that deprenyl REDUCES tyramine induced release of norepinephrine. As of January 2007 (Expert Opin Pharmacother. 2007 Jan;8(1):59-64) there have been "NO reports of hypertensive crisis in any patient receiving selegiline via this transdermal system at any of the three doses."
Many have combined high doses of non-selective MAOIs with stimulants like Ritalin and Adderall, with no ill effects. (note: adderall has been shown to increase levels of PEA by 1600%)
PEA, may be, in fact, safer than DLPA. DLPA converts to tyrosine-->dopa-->dopamine-->norepinephrine-->epinephrine -- all of which pose a greater risk of hypertensive crisis. It should also be noted that PEA has a half life of 0.4 minutes.
(Paterson, I. et al (1990) “2-Phenylethylamine: a modulator of catecholamine transmission in the mammalian central nervous system?” J Neurochem. 55, 1827-37. )
poster:djmmm
thread:724882
URL: http://www.dr-bob.org/babble/alter/20070114/msgs/724887.html