Posted by aabag on January 16, 2007, at 16:43:14 [reposted on January 18, 2007, at 20:44:52 | original URL]
In reply to Re: Gaba-a anxiolytics » aabag, posted by psychobot5000 on January 16, 2007, at 14:06:41
Perhaps I should have been more specific what I meant by "targeted" When I wrote a targeted GABA-A compound, I meant that the anxiolytic compound would target specific GABA-A receptor subgroups.
Gaba receptors are pentameric (5 subunits), and each combination, when agnoized, has different effects. So by targeting, I mean a compound which hits specific GABA-A receptor sub-types known to have an anxiolytic effect, not those with hypnotic effects. This is exactly what many insomnia medications do, which is why they are not anxiolytic.
poster:aabag
thread:723821
URL: http://www.dr-bob.org/babble/alter/20070114/msgs/723828.html