Posted by linkadge on November 9, 2006, at 8:36:08
In reply to MOA and COMT, posted by kiwiredbeach on November 9, 2006, at 4:12:00
The thing is that they don't break down the same cluster of neurotransmitters.
MAO-A generally responsable for the breakdown of
Ser,nor,dop,and some trace amines.
COMT Just norepinephrine, (and dopamine?)Anyhow, none of the metabilolic pathways, ie MAO-A,B, SERT,NET,DAT,COMT etc, fully overlap with another.
They often work to compensate for eachother.
Ie. if DAT was solely responsable for the metabolism of dopamine, then a dat inhibitor would result in dopamine overflow. Instead, other pathways can take over so as to prevent neurotoxicity.Linkadge
poster:linkadge
thread:701922
URL: http://www.dr-bob.org/babble/alter/20061013/msgs/701956.html