Posted by nolvas on October 8, 2006, at 5:10:12
In reply to How to substitute TMG for SAM-e?, posted by mila s on October 7, 2006, at 21:12:57
"The main disadvantage of SAMe supplementation is its very high cost. It is possible to stimulate the body’s endogenous production of SAMe by using supplemental Betaine (Trimethylglycine) + Folic Acid + Vitamin B12.
Trimethylglycine (TMG) is 100% Betaine and is purported to be the optimum form of Betaine for all uses other than correcting Hydrochloric Acid deficiency.""Anti-depression: By raising level of beneficial SAM (S-Adenosyl-Methionine).
Dose range: 500-1,500 mg daily"
http://www.raysahelian.com/trimethylglycine.html"Q. You have mentioned in your book, Mind Boosters that DMG and Trimethylglycine are possibly capable of providing much of the same anti-depressant actions as SAM-e, for less cost. I read somewhere that the action of a dose of SAM-e may be enhanced by taking some MSM at the same time. My guess is that would be due to an increase in methylation. Do you think that taking some MSM along with DMG or Trimethylglycine would likewise increase the effects of the DMG or Trimethylglycine? Do you agree with the concept of adding the MSM to the SAM-e?
A. You ask a good question. I have tried finding scientific studies on MSM but the published information on this nutrient is extremely limited. I don't know too much about MSM's cognitive effects, although it is known that it can easily cross the blood-brain barrier. My brief personal experience with this nutrient for a few days did not indicate that it had much effect on mood--unlike DMG, Trimethylglycine, and SAM-e--but I need to emphasize that my experience was very limited. If you do try the combination of MSM with other methyl donors, please let me know if you find a synergistic effect. In the meantime, if I come across any other information, I will make sure to post it."
poster:nolvas
thread:692859
URL: http://www.dr-bob.org/babble/alter/20060817/msgs/692917.html