Posted by Larry Hoover on December 29, 2005, at 5:19:41
In reply to Re: Linkadge..Tumeric as MAO inhibitor?, posted by linkadge on December 28, 2005, at 11:17:35
> The bottle contents were indicated in mass. I emptied the contents of the bottle, then filled the bottle with water to get a volumetric size of the bottle.
>
> From there, I just converted the ratio into something I needed.
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> I got 1g ~ 0.45 tsp.
>
> so 10g ~ 1.5 tbsp.
>
> Does that sound right ?
>
>
>
> LinkadgeYes, that sounds like a valid ratio of volume and mass.
Based on your calibration, 1 tsp. would be 2 grams (more or less), and a heaping teaspoon closer to 3.
That's the most I've ever taken, and only for anti-inflammatory effects. At that dose, once a day, I had better response than Vioxx 50 mg (high dose), twice a day.
So, I had massive COX inhibition, at much lower dose (closer to the low end of your turmeric paper re: MAOI effect). I'm rather concerned if you take this for an extended period. There is a lot we don't know about COX-mediated biochemistry, including issues such as rebound from inhibition.
Some of your antidepressant-like response might be mediated via COX, by the way. Inflammatory response has been linked to mood in a great number of studies, but nobody has tried to figure out if it's independent of e.g. analgesic effect observed in arthritis studies or cancer inhibition studies.
Turmeric has such a high colon-cancer inhibitory effect, it's been considered as a treatment, but computer simulations have shown that semi-synthetic analogs have greater activity yet.
My point in bringing these activities to your attention is to consider that herbal treatments are really massive polypharmacy experiments. There can be dozens, if not hundreds, of active components. Surely, not all of them are beneficial, or at least, beneficial in chronic intake.
Lar
poster:Larry Hoover
thread:592689
URL: http://www.dr-bob.org/babble/alter/20051208/msgs/593050.html