Posted by Larry Hoover on May 24, 2005, at 22:59:29
In reply to Re: pyroluria supps...my experience...it's WORKING !!! » joebob, posted by tealady on May 23, 2005, at 17:16:42
> a question..what is reduced glutathione?
>
> JanGlutathione is oxidized at the sulfhydryl (thiol) functional group of the cysteine residue.
Reduced glutathione (GSH) is glutathione ready to act. When it is oxidized, it forms a sulphur bridge (cystine bond) with another GSH molecule, forming a GSH dimer called GSSG. GSSG is then enzymatically reduced (requiring ATP) back to two GSH molecules.
Here's a nice little summary article:
http://www.thorne.com/pdf/journal/6-6/glutathione_monograph.pdfLar
P.S. Glutathione supplements are a waste of money. They're simply digested in the stomach. The rate limiting molecule in glutathione synthesis is cysteine. In fact, cysteine can reduce GSSG. So, cysteine can both go to form glutathione, and it can recycle it.
The article mentions some GSH transporters in the intestine. I do not believe oral GSH makes it that far, although others conclude that it does. I believe, instead, that the brush border secretes GSH into the lumen, and actively transports GSH and GSSG, to control concentrations and availability. Anyway....off to bed.
Lar
poster:Larry Hoover
thread:498689
URL: http://www.dr-bob.org/babble/alter/20050510/msgs/502543.html