Re: does b12 effect MAO-B ?? » linkadge

Posted by Larry Hoover on April 25, 2005, at 8:52:58

In reply to does b12 effect MAO-B ??, posted by linkadge on April 23, 2005, at 18:39:21

> I read that there was an association between b12 and MAO-B. Does this mean that b12 has a direct effect on MAO-B ??
>
> Thanks
>
> Linkadge
In senile dementias, severity of symptoms is positively correlated to MAO-B activity, but there is a stronger inverse correlation to vitamin B12 status.
Aging itself leads to increases in MAO-B, and it could be that some of the changes that come with age are accelerated in the senile dementias. At least in the sense of protecting the brain from the maximum effect of these aging processes, it makes sense to ensure that your intake of B12 is adequate, the older you are.
I don't see any evidence that the same effect is seen in younger people. It may well be true, but there is no evidence. However, it does speak to the effectiveness of selegiline at low doses, as an augment strategy.....taking MAO-B out of the picture might be a really good thing, overall.
Lar

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does b12 effect MAO-B ?? linkadge 4/23/05
Re: does b12 effect MAO-B ?? » linkadge Larry Hoover 4/25/05
Does MAO-B activity vary from person to person linkadge 4/25/05
i do think you are right about stress (nm) » linkadge joebob 5/4/05
Re: Does MAO-B activity vary from person to person » linkadge Chairman_MAO 5/5/05
Re: does b12 effect MAO-B ?? » Larry Hoover Chairman_MAO 5/5/05

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