Posted by Larry Hoover on November 25, 2004, at 5:23:14
In reply to Re: dopamine oxidation » Larry Hoover, posted by raybakes on November 12, 2004, at 14:11:16
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> > OK, you bum, you made me get out my textbooks.
>
> Sorry Lar :(Dude, I was teasing. I don't usually use my books.
> I see the oxidative stress as the root, and acidosis as the outcome.
>
> I can go with that!So, it still is oxidative stress that needs controlling, to avoid the acidotic response.
> > What is it, explicitly, that you do to improve buffering capacity? And separately, what do you do to support your mitochondria?
>
>
> Carnosine (good for detoxing aldehydes from mitochondrial lipid peroxidation), carnitine and creatine all work well for both.
>
> Do better with precursors - arginine and methyl factors for creatine - lysine and methyl factors for carnitine.Good tips, thanks.
> CoQ10 also needs methylation, and tyrosine, biopterin and cholesterol.
>
> Also looking at ways to reduce superoxide and peroxynitrite as they uncouple a lot of mitochondrial enzymes.I've been using inosine, and it certainly doesn't seem to have any adverse effects. It's totally inexpensive, and readily scavenges peroxynitrite. I'll leave the superoxide to my dismutase enzymes, which work best with lots of alphalipoic backing them up.
> The balance of arginine/NOS/biopterin/methylation seems important. Low biopterin or low arginine can switch NOS to produce superoxide instead of nitric oxide. Arginine without methyl factors can increase homocysteine.How?
> I'm being cautious with NAC at the moment because although I want to raise glutathione, I get the feeling that cysteine dioxygenase (interleukin 1, 6 and TNF alpha related I think) doesn't clear the excess of cysteine properly for me - my lungs burned when I last took NAC. Do badly with sulfites (triggers superoxide production from NADPH), taking molybdenum worsens my symptoms, but MSM improves them dramaticallyMSM takes the load off of methionine for sulphation. How are you with methionine?
> > One thing at a time, Ray. I must pace myself.
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> Sorry, hope that's not too much - I think I like forests more than trees!
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> RayYes, me too. In then end, it's what makes you feel better, not whether you can explain why it does so.
Lar
poster:Larry Hoover
thread:404137
URL: http://www.dr-bob.org/babble/alter/20041123/msgs/420045.html