Posted by KaraS on November 11, 2004, at 21:59:36
In reply to Re: dopamine autoreceptor problem, posted by linkadge on November 11, 2004, at 16:10:33
> I was taking celexa, but we dropped that.
>
> Still trying to determine the pros and con's of SSRI's
>
> Things should generally go back to the way they were after an SSRI discontinuation. It may take time, but I don't think they may any permanent changes.
>
> I'm not sure of the actual binding of amisulpride. I do know it blocks the d2, and d3 receptors, it addition to blocking dopamine autoreceptors.
>
> This would lead to enhaced dopamine functioning at the d1 receptor, but probably not much increase in dopamine at the d2/d3 receptors.
>
> I would continue with the selegeline and PEA.
> If your motivation/energy slowly improves over time then it is likely that the drug is indeed desensitizing the autoreceptor.
>
> Linkadge
>I just happened to be come across this post (I wasn't even looking for it) with more info on Amisulpride and the autoreceptors. Ironically the post was written to you. Here's the relevant paragraph:
"I use Amisulpride which is also an antagonist of Dopamines D2/D3 receptors. But at the dose I am taking (very low) it has more affinity to presynaptic receptors (called autoreceptors). If these are blocked then the release of Dopamine gets ENHANCED. So this drug has contradictory effects at low/high doses..."
Here's the entire link:
http://www.dr-bob.org/babble/20040825/msgs/383713.html
I may try this down the line but I think my first step will still be the selegiline. If it eventually goes from putting me to sleep to waking me up, then I'll know that it is working. Hopefully it will have some effect on depression sooner.K
poster:KaraS
thread:413185
URL: http://www.dr-bob.org/babble/alter/20041108/msgs/414798.html