Posted by Larry Hoover on September 5, 2004, at 10:22:21
In reply to Re: I've lost track......... » Larry Hoover, posted by Simus on September 3, 2004, at 0:10:58
> > I can't think of a single disorder where fish oils are contraindicated. If you can find such a reference, let me know, 'kay?
>
> It is because of the pyroluria condition. Dr. Edmond O`Flaherty has a very good Omega3 website http://www.omega3.20megsfree.com/whats_new.html where he included some of Dr. Walsh's work at the Pfeiffer clinic on pyrolurics. "We've had considerable success in using PUFA's (poly-unsaturated fatty acids) to treat persons with mental illness, but have found that omega-3 and omega-6 oils can cause clear worsening if given inappropriately. Pyrolurics need omega-6..... whereas most other patients need omega-3. There is a competition between o3 and o6 for zinc, B-6, and the delta 5,6 desaturases. The ideal would be to identify a person's biochemical individuality, with respect to PUFA's, then treat accordingly."I've only just begun to root out the truth within the theory, and it doesn't look good for Pfeiffer et al.
There are correlations between a sub-population of the mentally ill and nutritional status and pyrroles in urine. Correlation can be explained in four possible ways. A leads to B; B leads to A (identical correlation in both these cases); coincidence; or, both A and B are caused by an unmeasured entity (or entities) C (and D, etc.).
I am arriving at the conlusion that this latter case is the better explanation. Porphyria is a disorder of heme synthesis. Porphyrrins are essential protein-derived "shells" for the reactive metal ion in various molecules, such as chlorophyll, or hemoglobin. Porphyria has many variants, so it's hard to make generalizations, but one form is out-of-control synthesis of the pyrroles which are later turned into porphyrins. The excess pyrroles are dumped into urine by the kidneys. The pyrroles have numerous adverse effects, including psychosis and mood disturbance. Those adverse effects can be ameliorated by zinc and B6 supplements, in some cases. I believe that pyroluria (as a disorder) is an accidental re-discovery of porphyria, by someone who did not recognize its origin.
Lar
poster:Larry Hoover
thread:384584
URL: http://www.dr-bob.org/babble/alter/20040901/msgs/386640.html