Posted by taylor18 on November 10, 2003, at 17:24:44
In reply to Re: OPCs/Flavay for manic depression? » taylor18, posted by Larry Hoover on November 10, 2003, at 6:59:02
In my defense, you're attacking the quotes I gleaned from about 5 minutes of searching at Google.
However, this caught me:
> and it helps to regulate the nitric oxide production so that it stays in balance.Semantic frippery.
In response:
"...The high intake of polyphenols is thought to contribute to the beneficial cardiovascular effects of plant-centered diets. A putative mechanism underlying the cardioprotective activity is thought to be a plant phenol-induced increase of nitric oxide formation by the constitutive endothelial nitric oxide synthase. Twenty-eight phenols of different classes commonly occurring in plant foods were examined for their capability of enhancing the endothelial nitric oxide release of isolated porcine coronary arteries by direct real-time measurement of the luminal surface nitric oxide concentration with an amperometric microsensor. Additionally, the relaxing activity of the phenols was measured on porcine coronary rings. Quercetin, myricetin, leucocyanidol, and oligomeric proanthocyanidins induced the highest increases in nitric oxide release (delta[NO] > 8.5 nM )..."
"...Phenolic compounds at the range of 16-500 microM that inhibited NO production by > 50% without showing cytotoxicity were the flavonols quercetin and myricetin, the isoflavone daidzein, and the anthocyanins/anthocyanidins pelargonidin, cyanidin, delphinidin, peonidin, malvidin, malvidin 3-glucoside, and malvidin 3,5-diglucosides. Anthocyanins had strong inhibitory effects on NO production. Anthocyanin-rich crude extracts and concentrates of selected berries were also assayed, and their inhibitory effects on NO production were significantly correlated with total phenolic and anthocyanin contents. This is the first study to report the inhibitory effects of anthocyanins and berry phenolic compounds on NO production..."
More studies investigating the role of polyphenols in NO regulation:
Polyphenols:
Polyphenols are a broad family of naturally-occurring physiologically-active nutrients. They can be divided into four subgroups. The first group is called bioflavonoids. The next two groups are close cousins of bioflavonoids and are called anthocyanins and proanthocyanidins (OPCs). These are found primarily in the berry nectars. The last group is called xanthones. They are primarily found in Gentain and Chinese skullcap nectars.
poster:taylor18
thread:277840
URL: http://www.dr-bob.org/babble/alter/20031104/msgs/278311.html