Posted by Larry Hoover on September 21, 2003, at 7:20:38
In reply to Re: oxygen/ 5-HT2C receptor weight gain, posted by tealady on September 20, 2003, at 23:37:23
Hey Jan.
> In this chapter, the control of energy stores as fat is viewed as a feedback system. Leptin is perceived as a key afferent signal and glucocorticoids and the sympathetic nervous system through beta receptors as essential elements of this control system."
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> JanTwo things come to mind. The system is incredibly complex. I don't really spend a lot of time trying to understand the complexity. I try to focus on the manipulations that seem to make a difference. She generalizes to high-fat diet, whereas I know that it makes a huge difference which fat, not just total fat. I know fish oil shifts the balance. I don't need to know why, exactly.
We're not laboratory rodents. Not everything translates accurately.
> PS anyone know why some SSRI's have 5-HT2C antagonists? ..like why try to block that receptor?It's a coincidence. They're not trying to target it. They just acknowledge that it is affected, too. Because of individual differences in genes, the relative sensitivity of the different serotonin receptors will be different for each of us. Some people lose weight, some gain weight, on the same drug.
> Is it's function known..other than to help you lose weight perhaps when stimulated by serotonin?
The focus is on mood. Just like sexual side effects, these other effects are trivialized. As *if* they were trivial.
> Just asking as this was a common thing with fluoxetine and lexapro, citalopram..if I got it right
> JanYa.
Lar
poster:Larry Hoover
thread:261577
URL: http://www.dr-bob.org/babble/alter/20030903/msgs/262138.html