Posted by Larry Hoover on September 20, 2003, at 8:43:06
In reply to Oils - CLA » Larry Hoover, posted by tealady on September 14, 2003, at 4:41:37
Jan,
> > > Similarly it is found that some taking CLA's will convert down some wrong pathway to cause increased insulin resistance and make one prone to diabetesII....haven't tried that one and not going to
> I found the reference. Larrian had put it in her newsletter. Larrian was using CLA for quite a while with weight loss and improvement too, so perhaps it s worth trying at least in the short term
> ----------------
> The latest….from LARRIAN REPORTS
> The Essential Guide to a Healthy Lifestyle at Any Age
> September 5, 2002 -- Volume 3 Issue #8
> (ISSN: 1527-3482) -- Larrian Gillespie
>
> ~ WHY NOT TO USE CLA -
> Sad but true. I'm taking CLA off my list of recommended products
> in light of the recent studies published this month. As you may
> recall, some people reported they GAINED weight on CLA, but there
> was no research I could find to explain WHY or HOW, that is, until
> two studies came out in humans.
>
> It seems CLA has several isomers, or mirror images of itself.
> In mice, the Trans10cis12 ( t10c12) form caused weight loss and
> improved insulin sensitivity. However, when studied in obese humans,
> it did the opposite, causing elevated blood glucose levels, along
> with more insulin resistance and lower HDL levels along with mild
> weight loss. C9T11, the other isomer, caused weight gain while lowering triglycerides. The choice of response depended upon one's liver
> enzymes. So, supplements are NOT the way to go with this fatty
> acid. Although tyrosine and P5P may help shift the metabolism
> towards the T10c12, that isomer increases insulin resistance.
> This is NOT a good thing.
> Diabetes Care, 2002(25):1516-1521
> Diabetes, 2002(51):2037-2044
> -------------------Looks like you're right about CLA....
Lipids. 2003 Apr;38(4):377-86.
Modulation of body composition and immune cell functions by conjugated linoleic acid in humans and animal models: benefits vs. risks.
Kelley DS, Erickson KL.
Western Human Nutrition Research Center, ARS, USDA, Department of Nutrition, University of California Davis, Davis, California 95616, USA. dkelley@whnrc.usda.gov
We have reviewed the published literature regarding the effects of CLA on body composition and immune cell functions in humans and in animal models. Results from studies in mice, hamsters, rats, and pigs generally support the notion that CLA reduced depot fat in the normal or lean strains. However, in obese rats, it increased body fat or decreased it less than in the corresponding lean controls. These studies also indicate that t10,c12-CLA was the isomer that reduced adipose fat; however, it also increased the fat content of several other tissues and increased circulating insulin and the saturated FA content of adipose tissue and muscle. Four of the eight published human studies found small but significant reductions in body fat with CLA supplementation; however, the reductions were smaller than the prediction errors for the methods used. The other four human studies found no change in body fat with CLA supplementation. These studies also report that CLA supplementation increased the risk factors for diabetes and cardiovascular disease including increased blood glucose, insulin, insulin resistance, VLDL, C-reactive protein, lipid peroxidation, and decreased HDL. Most studies regarding the effects of CLA on immune cell functions have been conducted with a mixture of isomers, and the results have been variable. One study conducted in mice with the purified c9,t11-CLA and t10,c12-CLA isomers indicated that the two isomers have similar effects on immune cell functions. Some of the reasons for the discrepancies between the effects of CLA in published reports are discussed. Although significant benefit to humans from CLA supplementation is questionable, it may create several health risks in both humans and animals. On the basis of the published data, CLA supplementation of adult human diets to improve body composition or enhance immune functions cannot be recommended at this time.
Hugs,
Lar
poster:Larry Hoover
thread:259851
URL: http://www.dr-bob.org/babble/alter/20030903/msgs/261901.html