Posted by Hugh on July 29, 2023, at 14:35:25
In reply to Actions of Nefazadone as SSRI add-on, posted by porkpiehat on July 26, 2023, at 13:48:46
I used to take Serzone. I took it on its own, and I later took it in combination with Remeron. It made me very irritable. The higher the dose, the more irritable it made me.
I'm glad Serzone is working for you. Maybe it would have worked better for me if I'd taken a low dose like you're doing. Sometimes less is more. I've found this to be the case with lithium. Taking a tiny dose of lithium makes me feel better than a larger -- but still very low -- dose. And I've found this to be the case with low-dose naltrexone (LDN). The maximum dosage for LDN is 4.5 mg. LDN at 0.5 mg or 0.25 mg makes me feel better than 4.5 mg.
> I added a small dose of serzone/nefazadone to my Prozac, which I have been on almost 4 months. The idea was to offset some of the anhedonia, apathy, headache, and perhaps irritability that came with the prozac.
>
> Man, it worked far better than expected. It helped with anxiety that prozac wasn't addressing, lack of desire for human interactions, and the irritability and detachment that I increasingly get on SSRIs.
>
> There is a feeling of dizziness/impairment/fog that is becoming a problem. Worse than that is that instead of the easy sleep I had on Prozac, I can't get to sleep and if so I get. terrible night sweats and pretty bad dreams.
>
> I'm worried that I might be doing some damage. I'm also super curious about what is happening on a neuro/pharmacological standpoint.
>
> Here are some interesting points:
>
> -Prozac strongly inhibits the metabolism of both nefazodone and meta-Chlorophenylpiperazine (mCPP), its metabolite. Hence I'm not taking more than 50mgs at a time of serzone and my prozac is at 20mg.
>
> -mCCP is an ecstacy-like substance that acts almost opposite to the receptor blocking mechanism of serzone. I do feel this gooey, connected, cuddly, "this music is awesome" feeling. Everything that is missing in an SSRI essentially.
>
> -I'm also taking 100mg lamictal/day. The confusion and memory problems kinda feels like I felt when I first started taking Lamictal at higher doses.
>
> Im a little worried that I'm just offsetting the side effects of prozac by getting high on ecstacy, which doesn't seem tenable. Thoughts?
>
poster:Hugh
thread:1122146
URL: http://www.dr-bob.org/babble/20230117/msgs/1122147.html