Posted by Hugh on June 30, 2023, at 10:24:55
In reply to Re: Novel Antidepressants in the Pipeline, posted by SLS on June 29, 2023, at 20:53:10
Hi Scott,
> Do you think microdoses of psilocybin are as effective as psychedelic dosages? How often would you take microdoses? Once a day? Once a week?
>James Fadiman, probably the leading authority on psychedelic microdosing, says that he doesn't know if microdoses improve neuroplasticity, since virtually all of the research that's been done on psychedelics has been on doses far larger than microdoses. But Fadiman thinks it's very likely that microdosing improves neuroplasticity, because when people who've been microdosing for a while stop, many report that they continue to feel well.
Most people microdose psychedelics once every three days. Some people do it every other day; some do it two days on, two days off. However it's done, it's important to regularly take a day or two off to prevent tolerance from developing. Fadiman says that he tells people to microdose once every three days for the first month, and then to figure out their own schedule -- to do whatever seems right to them. He says that after the first month of microdosing, most people start doing it less than once every three days.
> It gets lonely when you chase all of your friends away with a manic / hypomanic episode. A few months ago, I suffered a horrendous episode of pain due to lumbar spinal stenosis. I couldn't walk without screaming. So, I screamed. I was prescribed prendisone. Then, I was put on meloxicam (Mobic), a NSAID. Fortunately, my pharmacist told me that meloxicam interacts with lithium to increase blood levels of lithium. I started to become toxic. It was a real mess.
>
> One week of mania can destroy a life more completely than months or years of depression. Believe it.
>I'm sorry to hear that. Try not to be so hard on yourself. For many years, you've done more than anyone to keep Psycho-Babble going. You've reached out to countless people to try to help them with your expertise. It's hard to imagine Psycho-Babble without you.
poster:Hugh
thread:1122108
URL: http://www.dr-bob.org/babble/20230117/msgs/1122116.html