Posted by SLS on April 10, 2023, at 20:46:02
In reply to Re: Does anyone still take aripiprazole (Abilify)? » SLS, posted by undopaminergic on April 10, 2023, at 11:01:35
Hi.
I'm truly sorry about your experience with reboxetine. I tried reboxetine, too. It produced a hideous suicidal depression. I even called my parents to let them know that I would be getting my affairs in order. I was riddled with anxiety and feelings of doom. I guess I was lucky that the drug left me with no persistent damage.
I did not try pramipexole. After trying bromocriptine and watching the transience of the improvement from taking it, I was not surprised that so many people on Psycho-Babble reported similar experiences produced by pramipexole. I couldn't justify trying it at any point along the way. However, I very rarely exclude any untried drug from consideration.
The drugs that gave me a big improvement during the first week that disappeared by the second week include bromocriptine, moclobemide, sulpiride, and amphetamine. Do you think there is any advantage to taking amisulpride over sulpiride?
> > Sorry. I lost my train of thought.
> >
> > Like I said, someone can have opposite reactions to the same drug depending on the one that preceded it.
> >
> > Effexor always produced a mild improvement for me, but nothing close to satisfactory. Still, I felt better on it than off of it.
> >
> > Three years ago, I tried vortioxetine for at least four weeks. It produced intolerable brain-fog and a sense of detachment from my surroundings. I stopped taking it. Having no better ideas at the time, I asked to go back on Effexor until something new came along.
> >
> > When I reintroduced Effexor, I experienced a torturous and painful brain-fog. Not only did my depression not improve, it became significantly worse. This was not the Effexor that I knew.
> >
> > Wash-out periods are not just to allow a drug to clear the bloodstream. It also allows the brain time to reregulate itself back to a baseline similar to what had existed before drug exposure.
> >
> > Think about how neuroscientists gather information by exposing a rat to one compound to see how it affects its reaction to a second compound. This is called "pre-treatment". One experiment might be to see how pre-treating a rat with a 5-HT7 antagonist (vortioxetine) changes the way the rat reacts to Effexor. If vortioxetine upregulates 5-HT7 receptors after prolonged exposure, will introducing Effexor afterwards produce more anxiety or less anxiety compared to Effexor alone?
> >
> > Perhaps we should pay more attention to this when evaluating the therapeutic worth of a drug.
> >
> >
> > - Scott
> Yes.
>
> Pramipexole was the only drug I tried that was anti-anhedonic -- I got my sense of reward back. However, it apparently desensitised my dopamine D3/D2 receptors, so that the same drug would no longer work, despite a period of wash-out.
>
> Sulpiride yielded a powerful (more so than methylphenidate) "motivational" stimulant effect at first, but apparently desensitised my dopamine autoreceptors, so that the same drug would no longer make a difference. Then I used selegiline for a while and some of the initial effects of sulpiride came back -- maybe selegiline re-sensitised the autoreceptors.
>
> Reboxetine changed my brain permanently, so that I became more depersonalised-derealised -- my emotions were numbed, so that experiences that used to bring me to tears would no longer touch me. It was a welcome effect at the time, but now I wonder what my life would have been without it.
>
> -undopaminergic
- Scott
Some see things as they are and ask why.
I dream of things that never were and ask why not.The only thing necessary for the triumph of evil is that good men do nothing.
poster:SLS
thread:1121982
URL: http://www.dr-bob.org/babble/20230117/msgs/1122009.html